Results 51 to 60 of about 338,240 (315)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg²⁺/Ca²⁺ ATPase Ca²⁺ Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus

Brain Sciences, 2020
Loss of intracellular calcium homeostasis is an established mechanism associated with neuronal dysfunction and status epilepticus. Sequestration of free cytosolic calcium into endoplasmic reticulum by Mg2+/Ca2+ adenosinetriphosphatase (ATPase) is ...
Laxmikant S. Deshpande, Robert J. DeLorenzo, Severn B. Churn, J. Travis Parsons   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Impact of chronic kidney disease stage on seizure frequency and severity in pediatric epilepsy patients

BMC Nephrology
Background Chronic Kidney Disease (CKD) and epilepsy are common comorbidities in children; their clinical interaction in terms of seizure frequency and severity has been poorly explored.
Xingjia Tang, Yang Shen, Chongfeng Chen, Yituan Xie, Rui Liu, Meiyu Zhou, LiMin Xiang, Andleeb Asghar   +7 more
doaj   +1 more source

GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity

, 2010
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their ability to synchronize electrical activity. To investigate this, one option is to compare wild-type (WT) animals with those lacking the gene for connexin36 (Cx36 ...
Melin, Sofia M., Jacobson, Gregory M., Voss, Logan J., Sleigh, James W,, Sleigh, James W., Gregory Jacobson, James W. Sleigh, Jacobson, Gregory,, Sofia Melin, Voss, Logan J,, Melin, Sofia,, Logan J. Voss   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Diffusion Tensor Imaging and Quantitative Magnetic Resonance Volumetric Assessment in the Diagnosis of Hemimegalencephaly: A Case Report

대한영상의학회지, 2019
A 27-year-old female presented with repeated seizures. As the left frontal lobe volume was enlarged in comparison with the right frontal lobe, hemimegalencephaly was suggested.
Seung-Jin Yoo, Ji Young Lee, Young-Jun Lee, Dong Woo Park, Tae-Yoon Kim, Hee-Jin Kim   +5 more
doaj   +1 more source

Envenomation Seizures [PDF]

The Neurohospitalist, 2017
Insect sting-related envenomation rarely produces seizures. We present a patient with confusion and seizures that began 24 hours after a yellow jacket (wasp) sting. Given the rapid onset and resolution of symptoms, as well as accompanying dermatological and orbital features, and the lack of any infectious or structural abnormalities identified, the ...
Ghulam Abbas, Kharal, Richard Ryan, Darby, Adam B, Cohen   +2 more
openaire   +2 more sources

Joint modelling of event counts and survival times [PDF]

, 2009
We consider the analysis of data from the MRC Multicentre Trial for Early Epilepsy and Single Seizures (MESS), which was undertaken to assess the differences between two policies: immediate, or deferred treatment in patients with single seizures or ...
Rogers, Jennifer Kaye, Hemming, Karla, Hutton, Jane   +2 more
core