Results 51 to 60 of about 589,280 (296)

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish. [PDF]

open access: yes, 2019
Seizures are characterized by hypersynchronization of neuronal networks. Understanding these networks could provide a critical window for therapeutic control of recurrent seizure activity, i.e., epilepsy.
Baraban, Scott C, Liu, Jing
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

The comparison of inflammatory markers in pentylenetetrazole-induced acute epileptic seizure model and chronic epilepsy model in rats

open access: yesCumhuriyet Science Journal, 2020
Recent studies have provided important evidence that neuroinflammation has an effective role in epilepsy pathophysiology. However, it is not clear that the occurrence of neuroinflammation is related to one epileptic seizure or repeating seizures ...
Ahmet Şevki Taşkıran   +1 more
doaj   +1 more source

Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine. [PDF]

open access: yes, 2018
OBJECTIVE: To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when ...
Abou-Khalil   +11 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Backpropagation Artificial Neural Network To Detect Hyperthermic Seizures In Rats [PDF]

open access: yes, 2002
A three-layered feed-forward back-propagation Artificial Neural Network was used to classify the seizure episodes in rats. Seizure patterns were induced by subjecting anesthetized rats to a Biological Oxygen Demand incubator at 45-47ºC for 30 to 60 ...
Sinha, Mr Rakesh Kumar
core  

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright   +13 more
wiley   +1 more source

Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats

open access: yesArchives of Epilepsy, 2021
Objectives:This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling.Methods:The rats were divided into three groups: Control group ...
Ozlem ERGUL ERKEC   +6 more
doaj   +1 more source

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