Results 61 to 70 of about 267,487 (268)

Case report: Bridging limbic network epilepsy with psychiatric, memory, and sleep comorbidities: case illustrations of reversible psychosis symptoms during continuous, high-frequency ANT-DBS

Frontiers in Network Physiology
The network nature of focal epilepsy is exemplified by mesial temporal lobe epilepsy (mTLE), characterized by focal seizures originating from the mesial temporal neocortex, amygdala, and hippocampus.
Lydia Wheeler, Lydia Wheeler, Samuel E. Worrell, Irena Balzekas, Irena Balzekas, Jordan Bilderbeek, Dora Hermes, Paul Croarkin, Steven Messina, Jamie Van Gompel, Kai J. Miller, Vaclav Kremen, Vaclav Kremen, Vaclav Kremen, Gregory A. Worrell, Gregory A. Worrell   +15 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Vitamin D content and prevalence of vitamin D deficiency in patients with epilepsy: a systematic review and meta-analysis

Frontiers in Nutrition
IntroductionThe prevalence of vitamin D deficiency and vitamin D levels in patients with epilepsy (PWE) were systematically evaluated, and the differences between subgroups were analyzed.MethodWe identified all articles investigating the prevalence of ...
Yuanyuan Liu, Chao Gong, Jiawei Li, Xin Ning, Pei Zeng, Luchuan Wang, Beibei Lian, Jiahao Liu, Liya Fang, Jin Guo, Jin Guo   +10 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Neurocysticercosis detected by targeted next-generation sequencing of cerebrospinal fluid: a case report

Frontiers in Neurology
The patient, a middle-aged male with a long history of the disease, had experienced recurrent headaches for 26 years and episodic shaking of the right limb with slurred speech for the past month.
Xintong Ren, HuiQin Sun, Yanghong Cheng, Yunzhou Zhang, Daiquan Gao   +4 more
doaj   +1 more source

Interactions of caffeine and nitric oxide on pentylenetetrazole-induced clonic and tonic seizures in mice [PDF]

Basic and Clinical Biochemistry and Nutrition
Background: Caffeine, a non-selective antagonist of adenosine receptors (ARs), may affect the anticonvulsant properties of adenosine through modulation of the nitric oxide (NO) pathway.Objectives: This study aimed to investigate the impact of caffeine ...
Hassan Jamali, Azhdar Heydari
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The Assessment of the Efficacy, Safety, and Challenges of Ketogenic Diet Therapy in Children with Epilepsy: The First Experience of a Single Center

Medicina
Background and Objectives: Ketogenic diet therapy (KDT) has been used as a non-pharmacological treatment for childhood refractory epilepsy. Its efficacy and safety have been described in numerous studies and reviews.
Jurgita Karandienė, Milda Endzinienė, Karolina Liaušienė, Giedrė Jurkevičienė   +3 more
doaj   +1 more source

The Relationship Between Seizure After Ischemic Stroke and Microbleeds

Archives of Epilepsy, 2020
Objectives:Although ischemic stroke is known to be related to epilepsy, the relationship between epilepsy and microbleeds has not been fully described. In this study, we aimed to find out the relationship between the microbleeds and epilepsy after stroke.
Eylem ÖZAYDIN GÖKSU, Ayşe Eda PARLAK, Şennur DELİBAŞ KATI, Fatma GENÇ   +3 more
doaj   +1 more source