Results 131 to 140 of about 191,939 (298)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Ki-67 overexpression in WHO grade II gliomas is associated with poor postoperative seizure control

, 2013
PurposeSeizures are the most common initial symptom in patients with low-grade gliomas, and approximately 30% of these patients still suffer from epilepsy after gross-total resection of the tumour.
Ruofei, Liang, Yanhui, Liu, Yingjun, Fan, Qiao, Zhou, Qing, Mao, Shuang, Liu, Yanwu, Yang, Yuan, Yang, Xiang, Wang   +8 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Seizure Control and Memory Impairment Are Related to Disrupted Brain Functional Integration in Temporal Lobe Epilepsy

, 2019
Brain functional integration can be disrupted in patients with temporal lobe epilepsy (TLE), but the clinical relevance of this disruption is not completely understood.
이향운, 유정현
core   +1 more source

Slower alpha rhythm associates with poorer seizure control in epilepsy [PDF]

, 2018
Objective: Slowing and frontal spread of the alpha rhythm have been reported in multiple epilepsy syndromes. We investigated whether these phenomena are associated with seizure control.Methods: We prospectively acquired resting-state EEG in 63 patients ...
Pawley, Adam David, Barker, Gareth John; id_orcid, Brunnhuber, Franz, Abela, Eugenio Cecilio; id_orcid, Yaakub, Siti Nurbaya, Elwes, Robert D. C., Richardson, Mark Philip; id_orcid, Chowdhury, Fahmida A., Tangwiriyasakul, Chayanin; id_orcid   +8 more
core   +1 more source

Post-stroke epilepsy in Oman: Prevalence, clinical profile, and treatment outcomes

South Sudan Medical Journal
Introduction: Post-stroke epilepsy (PSE), defined as unprovoked seizures occurring more than seven days after stroke onset, is a frequent neurological complication with variable incidence and outcomes.
Khalid Mohammed Ali , Tarig Fadelelmoula , Juhaina Al Saidi , Hawwa Al Fazari, Muzna Al Rahbi , Reem Hamed Al Qarni , Ali Al Reesi , Elham Mohammed , Hamed Al Reesi   +8 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

SerumTrace Elements in Febrile Seizure: A Case-Control Study

, 2016
 How to Cite This Article: Namakin K, Zardast M, Sharifzadeh Gh, Bidar T, Zargarian S. Serum Trace Elements in Febrile Seizure: A Case-Control Study. Iran J Child Neurol. Summer 2016; 10(3):57-60.  AbstractObjectiveFebrile seizure (FS) is one of the most
ZARGARIAN, Toktam, ZARDAST, Mahmoud, NAMAKIN, Kokab, BIDAR, Samaneh, SHARIFZADEH, Gholamreza   +4 more
core   +1 more source