Results 81 to 90 of about 191,939 (298)
On the Complete Control of Epileptic Seizures by Luminal [PDF]
The American Journal of the Medical Sciences, 1920 n ...
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Hemifacial Seizure of Cerebellar Ganglioglioma Origin: Seizure Control by Tumor Resection [PDF]
Epilepsia, 2001 Summary: The cerebellum is known to have an inhibitory effect on seizures. Nevertheless, cerebellar dysplastic lesions can be epileptogenic. A 4‐month‐old infant had paroxysmal facial contractions; tachypnea and nystagmoid eyeball and tremulous movements were occasionally combined.
J H, Chae +5 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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ChildrenObjectives: Drug-resistant epilepsy (DRE) remains a major challenge in pediatric neurology, as many children fail to achieve seizure control despite appropriate medications. Vagus nerve stimulation (VNS) offers an effective adjunctive treatment; however,
Müge Baykan +4 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Dual mechanism of anti-seizure medications in controlling seizure activity
Brain CommunicationsAbstract Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by curtailing existing seizure activity early or by selectively suppressing certain seizure activity patterns from emerging.
Guillermo M Besné +14 more
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Perioperative Epileptic Seizure Incidence in Glioma Patients
, 2019 Objectives:The aim of this study was to evaluate the incidence of epileptic seizures in the perioperative period in patients who were diagnosed with a glial tumor.Methods:This was a retrospective clinical study of the hospital files of 39 patients ...
Sertaç İŞLEKEL, Ali AKAY
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, 2017 In the comprehensive management of epilepsy, both preventive pharmacological treatment and awareness of possible seizure precipitating factors are important. The true cause of seizure generation is often hard to disentangle, as triggers often are obscure
Samsonsen, Christian
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