Results 101 to 110 of about 191,939 (298)

Clinical courses of pure sleep epilepsies

, 1998
This study aims to understand seizure control outcomes and the risk of developing new wake seizures (WS) related to the different types of pure sleep epilepsies (SE), which is important in making rational management plans.
박수철, 김원주, 이병인
core   +1 more source

Cerebral blood flow increases in idiopathic generalized epilepsy and its relationship with mood dysfunction

Epilepsia Open
Objective To investigate the relationship between cerebral blood flow (CBF), seizure control, and mood regulation in idiopathic generalized epilepsy (IGE), we hypothesized that higher CBF in mood‐regulating regions would be associated with greater mood ...
Yun Lien, Ayushe A. Sharma, William R. Willoughby, Anna Moyana, Jennifer Pilkington, Ja’ Kaiya Bryant, Adam M. Goodman, Goutham Selladurai, Lawrence W. Ver Hoef, Jerzy P. Szaflarski, Jane B. Allendorfer   +10 more
doaj   +1 more source

LUMINAL THERAPY IN THE CONTROL OF EPILEPTIC SEIZURES [PDF]

Archives of Neurology And Psychiatry, 1921
Notwithstanding the many ingenious hypotheses advanced to explain epilepsy, it still must be assumed that it is a disease of unexplained etiology. In the present state of information, it might be best regarded as the result of an increased irritability of the cerebral cortex, occurring as an expression of organ inferiority, with the seizures as ...
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Seizure control in antiepileptic drug-treated pregnancy

, 2008
This brief report covers an analysis of 7 years outcome data from the Australian Register of Antiepileptic Drugs in Pregnancy. In studying the control of antiepileptic drug-treated epileptic seizures during pregnancy, it was found that pregnancy had ...
Hitchcock, A, Frank J. E. Vajda, Janet Graham, Graham, J, Terence O'Brien, Vajda, F J E, Cecilie Lander, Alison Hitchcock, Mervyn Eadie, Eadie, M, O'Brien, T, Lander, C   +11 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Epilepsy in Tanzanian children: association with perinatal events and other risk factors. [PDF]

, 2012
PURPOSE: To define the prevalence and risk factors for epilepsy in children in a rural district of Tanzania by conducting a community-based case-control study.
Walker, Richard, Neville, BGR, Neville, Brian GR, Whittaker, R, Walker, R, Newton, CRJC, Burton, Matthew J, Neville, BG, Burton, Kathryn J, Hunter, Ewan, Mankad, K, Mankad, Kshitij, Newton, Charles, Todd, Jim, Whittaker, Roger, Newton, Charles RJC, Burton, KJ, Hunter, E, Newton, CR, Rogathe, J, Burton, MJ, Rogathe, Jane, Todd, J   +22 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Molecular Basis of GABA Aminotransferase Inhibition in Epilepsy: Structure, Mechanisms, and Drug Development

Current Issues in Molecular Biology
Epilepsy affects approximately 50 million people worldwide, with nearly one-third of patients experiencing inadequate seizure control with conventional anti-epileptic drugs.
Muhammad Yasir, Jongseon Choe, Jin-Hee Han, Wanjoo Chun   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source