Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
SLA based cloud service composition using genetic algorithm [PDF]
Cloud computing tends to provide high quality on-demand services to the users. Numerous services are evolving today. Functionally similar services are having different non-functional properties such as reliability, availability, accessibility, response ...
N Sasikaladevi, Sasikaladevi, N
core +1 more source
Evolutionary Schema of Modeling Based on Genetic Algorithms
In this paper, I propose a populational schema of modeling that consists of: (a) a linear AFSV schema (with four basic stages of abstraction, formalization, simplification, and verification), and (b) a higher-level schema employing the genetic algorithm (
Stacewicz Paweł
doaj +1 more source
A Selection Process for Genetic Algorithm Using Clustering Analysis
This article presents a newly proposed selection process for genetic algorithms on a class of unconstrained optimization problems. The k-means genetic algorithm selection process (KGA) is composed of four essential stages: clustering, membership phase ...
Adam Chehouri +4 more
doaj +1 more source
Two-stage hybrid genetic algorithm for robot cloud service selection
Robot cloud service platform is a combination of cloud computing and robotics, providing intelligent cloud services for many robots. However, to select a cloud service that satisfys the robot’s requirements from the massive services with different QoS ...
Lei Yin +5 more
doaj +1 more source
Boosting Genetic Algorithms with Self-Adaptive Selection [PDF]
In this paper we evaluate a new approach to selection in genetic algorithms (GAs). The basis of our approach is that the selection pressure is not a superimposed parameter defined by the user or some Boltzmann mechanism. Rather, it is an aggregated parameter that is determined collectively by the individuals in the population. We implement this idea in
Eiben, A.E., Schut, M.C., de Wilde, A.R.
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A new genetic algorithm for multi-label correlation-based feature selection. [PDF]
This paper proposes a new Genetic Algorithm for Multi-Label Correlation-Based Feature Selection (GA-ML-CFS). This GA performs a global search in the space of candidate feature subset, in order to select a high-quality feature subset is used by a multi ...
Jungjit, Suwimol, Freitas, Alex A.
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
GCMD: Genetic Correlation Multi-Domain Virtual Network Embedding Algorithm
With the increase of network scale and the complexity of network structure, the problems of traditional Internet have emerged. At the same time, the appearance of network function virtualization (NFV) and network virtualization technologies has largely ...
Peiying Zhang +5 more
doaj +1 more source

