Results 51 to 60 of about 242,339 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

FastTree-Guided Genetic Algorithm for Credit Scoring Feature Selection

Computers
Feature selection is pivotal in enhancing the efficiency of credit scoring predictions, where misclassifications are critical because they can result in financial losses for lenders and exclusion of eligible borrowers. While traditional feature selection
Rashed Bahlool, Nabil Hewahi, Youssef Harrath   +2 more
doaj   +1 more source

Modified Floating Search Feature Selection Based on Genetic Algorithm

MATEC Web of Conferences, 2018
Classification performance is adversely impacted by noisy data .Selecting features relevant to the problem is thus a critical step in classification and difficult to achieve accurate solution, especially when applied to a large data set. In this article,
Homsapaya Kanyanut, Sornil Ohm
doaj   +1 more source

Compare Between Genetic Algorithm and Clonal Selection Algorithm To Pattern Recognition Latin's Numbers [PDF]

مجلة التربية والعلم, 1970
This work involves the use  some of Artificial intelligence techniques algorithms which are genetic algorithm and artificial immune system algorithm- clonal selection algorithm.
Maha Mohammed
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Self-Tune Linear Adaptive-Genetic Algorithm for Feature Selection

IEEE Access, 2019
Genetic algorithm (GA) is an established machine learning technique used for heuristic optimisation purposes. However, this natural selection-based technique is prone to premature convergence, especially of the local optimum event.
Ching Sheng Ooi, Meng Hee Lim, Mohd Salman Leong   +2 more
doaj   +1 more source

Research On Energy-saving Operation Of High-speed Trains Based On Improved Genetic Algorithm

Journal of Applied Science and Engineering, 2022
The traditional genetic algorithm has been widely used in energy-saving optimization of train operation, but due to the uncertainty of the evolution direction of it’s population chromosomes, it has caused some problems such as a large amount of local ...
Hongxia Niu, Tao Hou, Yu Chen
doaj   +1 more source

Optimisation of the weighting functions of an H_∞ controller using genetic algorithms and structured genetic algorithms [PDF]

, 2008
In this paper the optimisation of the weighting functions for an H_∞ controller using genetic algorithms and structured genetic algorithms is considered. The choice of the weighting functions is one of the key steps in the design of
McGookin, E.W., Murray-Smith, D.J., Alfaro-Cid, E.   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Genetic Algorithm Based Feature Selection Technique for Electroencephalography Data

Applied Computer Systems, 2019
High dimensionality is a well-known problem that has a huge number of highlights in the data, yet none is helpful for a particular data mining task undertaking, for example, classification and grouping. Therefore, selection of features is used frequently
Ali Tariq, Nawaz Asif, Sadia Hafiza Ayesha   +2 more
doaj   +1 more source