Results 61 to 70 of about 6,256,599 (289)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
3D freeform component fixture design optisation using a genetic algorithm [PDF]
, 2007 This paper details an application of genetic algorithms (GA) developed for the optimisation of fixture locator positioning for 3D freeform components. Based on the information of the workpiece, a genetic algorithm based approach is applied to determine ...
Chen, Xun, Yeung, Ka Yiu
core +4 more sources
3-D Fixture Layout Design System Based on Genetic Algorithm [PDF]
, 2010 Designing a fixture layout is the primary task of fixture design, which consists of determining the different combinations of locators and clamping scheme.
Chen, Xun, Yeung, Ka Yiu
core +3 more sources
Modelling of a Roulette Wheel Selection Operator in Genetic Algorithms Using Generalized Nets [PDF]
Bioautomation, 2009 The apparatus of Generalized Nets (GN) is applied here to a description of a selection operator, which is one of the basic genetic algorithm operators. The GN model presented here describes roulette wheel selection.
Pencheva T., Atanassov K., Shannon A.
doaj
Feature Selection for Image Retrieval based on Genetic Algorithm
International Journal of Interactive Multimedia and Artificial Intelligence, 2016 This paper describes the development and implementation of feature selection for content based image retrieval. We are working on CBIR system with new efficient technique. In this system, we use multi feature extraction such as colour, texture and shape.
Rashmi R. Welekar, Preeti Kushwaha
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Feature selection for modular GA-based classification [PDF]
, 2004 Genetic algorithms (GAs) have been used as conventional methods for classifiers to adaptively evolve solutions for classification problems. Feature selection plays an important role in finding relevant features in classification.
Guan, SU, Zhu, F, Zhu, F., Guan, S.
core +1 more source
Ship Type Selection and Cost Optimization of Marine Container Ships Based on Genetic Algorithm
Applied SciencesIn the context of the deep-sea transportation supply chain, this paper addresses the complex decision-making problem of vessel allocation and carbon emission optimization for container shipping routes.
Ping Xiao, Haiyan Wang
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source