Results 231 to 240 of about 3,585,940 (324)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Using Whole-Genome Sequencing Data Reveals the Population Structure and Selection Signatures for Reproduction Traits in Duolang Sheep. [PDF]

Animals (Basel)
Wang K, Li Q, Niu Z, Xue Z, Li S, Yan J, Chen Y, Zhang Y, Shi H, Ding X.   +9 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Genomic analysis reveals genetic diversity and selection signatures of the Yantai Black pig during domestication and breeding. [PDF]

Front Genet
Qin M, Ma C, Liang M, Zhang Y, Wang Z, Wang J, Li G, Sha Y, Jin P, Ju L, Liu X, Zeng Y, Li R.   +12 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Genomic diversity and selection signatures in Asian Zebu Cattle: insights into adaptation and genetic erosion. [PDF]

Sci Rep
Mavunga TK, Sölkner J, Mészáros G, Pichler R, Ramasamy S, Manomohan V, Kumar SR, Abbas K, Hussain T, Babar ME, Lokugalappatti LGS, Thandar E, Phem M, Tum S, Bhuiyan MMU, Purevdorj M, Barbato M, Periasamy K.   +17 more
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Integrating whole-genome resequencing data reveals adaptive selection signatures in sheep populations under extreme environments. [PDF]

BMC Genomics
Pang Z, Yang P, Cai K, Wang W, Afe AE, Pan Y, Qiao L, Liu W.   +7 more
europepmc   +1 more source

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

Integrating genome-wide association analysis and selection signatures to identify the key genes affecting the primary economic traits of pigs. [PDF]

BMC Genomics
Ji H, Tang D, Qin R, Rao K, Lu Z, Pang Y, Cen Y, Lin X, Chen F, Zhao Y, Zhuang Z.   +10 more
europepmc   +1 more source