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Selective Internal Radiation Therapy Dosimetry
Future Oncology, 2014Dosimetry is the calculation of radiation energy absorbed by tissue (measured in Grays [Gy]) as a result of exposure to indirect and direct ionizing radiation. The strength of a radioactive source is called its activity, which is defined as the rate at which the isotope decays over time.
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The Evidence for Resection Post-Selective Internal Radiation Therapy
Future Oncology, 2014Selective internal radiation therapy (SIRT) has become a well-established modality for the palliative treatment of primary and metastatic liver tumors. As a consequence of the growing experience with this treatment, research has recently focused on its potential as a component in the management of patients for curative treatment.
Benjamin, Garlipp, Christiane J, Bruns
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Selective Internal Radiation therapy
2008Primary and secondary liver tumours are common malignancies associated with unsatisfactory treatment and bad prognosis. Hepatocellular carcinoma (HCC) ranks among the 10 most common cancers worldwide and is the most common primary malignancy of the liver.
A. Al-Nahhas +4 more
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Selective internal radiation therapy: validation of intraoperative dosimetry.
Radiology, 1990In selective internal radiation (SIR) therapy of hepatic metastases, tumor vasculature is preferentially embolized with high-energy beta-emitting yttrium-90-labeled microspheres. To enable accurate estimation of the resultant absorbed radiation doses to tissues, an intraoperative beta detection probe is used to scan the liver surface.
M A, Burton +3 more
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Yttrium-90 Selective Internal Radiation Therapy
2017Yttrium-90 Selective internal radiation therapy is a growing part of the field of liver-directed radiation therapy. This technique involves the delivery of radioactive microbeads directly into liver tumors via the blood supply. There are presently two devices available to deliver Y90, with different techniques and clinical considerations for the two ...
D. Thor Johnson, Adam Leon Kesner
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Selective internal radiation therapy for liver metastases from colorectal cancer
Cancer Treatment Reviews, 2016Liver metastases are often the dominant site of metastatic disease in colorectal cancer. Selective internal radiation therapy (SIRT) involves embolising radiolabeled spheres (SIR-Spheres) into the arterial supply of the liver. This review assesses the effectiveness and toxicity of SIRT in the treatment of metastatic colorectal cancer liver metastasis ...
Townsend, A. +3 more
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Selective Internal Radiation Therapy
2007The majority of primary and secondary malignant hepatic tumors are not suitable for surgical resection, which makes systemic chemotherapy treatments and/or local ablative therapies important components of intention-to-treat concepts or palliation. Tumor load and type of response determine the efficacy of these therapies.
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Cost of Selective Internal Radiation Therapy Versus Other Modalities
Future Oncology, 2014Evaluation of comparative effectiveness and cost–effectiveness is an essential component in the integration of new technologies into medical management, with data from prospective clinical trials (e.g., health-related quality of life using validated tools) being mandated by most health authorities.
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Physica Medica, 2019
Dose rates from 30 patients, treated over a 3-year period (2016-2018) were measured post therapy in contact with the patients' upper abdomen and at distances of 0.3 m and 1 m. Dose rates were compared with theoretical predictions and used as model inputs for calculating radiation doses received by family members and carers based on interaction patterns
Seán Cournane +5 more
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Dose rates from 30 patients, treated over a 3-year period (2016-2018) were measured post therapy in contact with the patients' upper abdomen and at distances of 0.3 m and 1 m. Dose rates were compared with theoretical predictions and used as model inputs for calculating radiation doses received by family members and carers based on interaction patterns
Seán Cournane +5 more
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Selective Internal Radiation Therapy-induced Extrahepatic Injury
American Journal of Surgical Pathology, 2009Selective internal radiation therapy (SIRT) using Yttrium microspheres is a novel therapeutic approach to the localized treatment of hepatic tumors. It provides a distinct advantage over conventional external beam radiation in that its targeted nature allows the directed delivery of high doses of radiation to tumors while sparing the surrounding ...
Clinton D, Crowder +5 more
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