Results 71 to 80 of about 1,067,600 (243)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

MAPPING DISTURBANCE FROM SELECTIVE LOGGING IN TROPICAL FORESTS OF THE YUCATAN PENINSULA, MEXICO

open access: yesTropical and Subtropical Agroecosystems, 2020
Background. Mapping selective logging impacts on the Yucatan Peninsula is important to pursuing carbon emissions reduction and biodiversity conservation goals. Objective. To evaluate the effectiveness of applying remote sensing techniques using LANDSAT 8
I.U. Hernandez-Gomez   +4 more
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

The extent and causes of illegal logging: an analysis of a major cause of tropical deforestation in Indonesia [PDF]

open access: yes, 2001
This paper considers the scale and underlying causes of recent high rates of deforestation in Indonesia. Its extent during 1997-98 is analysed using a materials balance model, the results of which demonstrate the seriousness of the problem at a time when
Palmer, C.
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Using multi-temporal satellite data to evaluate selective logging in [PDF]

open access: yes, 1998
. Clear cutting in tropical forests is common. A newer phenomenon, selective logging, is evident in Amazonia when examined with high-resolution satellite data. We have quanti® ed selective logging by digitizing satellite imagery and have found that it is
P Lefebvre, T A Stone
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A methodological framework to assess the carbon balance of tropical managed forests

open access: yesCarbon Balance and Management, 2016
Background Managed forests are a major component of tropical landscapes. Production forests as designated by national forest services cover up to 400 million ha, i.e. half of the forested area in the humid tropics.
Camille Piponiot   +8 more
doaj   +1 more source

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