Results 61 to 70 of about 1,067,600 (243)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Experimental assessment of forest flammability after selective logging in the Brazilian Amazon
Communications Earth & EnvironmentTropical forests, strongholds of biodiversity and carbon storage, face increasing threats from selective logging and fires. Selective logging disrupts forest structure, leaving canopy gaps where commercially valuable trees once stood, potentially ...
Manoela S. Machado +4 more
doaj +1 more source
Can traditional selective logging secure tree regeneration in cloud forest?
iForest - Biogeosciences and Forestry, 2017 Unplanned selective logging for charcoal and firewood is a common practice in tropical montane cloud forest (TMCF), a high priority ecosystem for biodiversity conservation at the global scale.
Ortiz-Colín P +3 more
doaj +1 more source
Optimal selective logging regime and log landing location models: a case study in the Amazon forest [PDF]
Acta Amazonica, 2018 Reduced-impact logging is a well known practice applied in most sustainable forest management plans in the Amazon. Nevertheless, there are still ways to improve the operational planning process.
Paulo Henrique da SILVA +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Seasonal invertebrate communities in multiple use jarrah forests. Implications for conservation and management [PDF]
, 2004 The response of ground-dwelling jarrah forest invertebrates to logging (but not a post-harvest burning) was examined in the Kingston, Warrup and Winnejup forest blocks, approximately 25 km north-east of Manjimup in the south-west of Western Australia ...
Friend, G. +3 more
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source