Results 91 to 100 of about 7,245 (254)

Ulipristal acetate in uterine fibroids treatment

Гинекология, 2013
Ulipristal acetate is a selective progesterone receptor modulator, characterized by partial tissue-specific antiprogesteron effect, which is used in order to prepare uterine cancer patients for surgery.
V V Korennaya, N M Podzolkova
doaj  

Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones

Reproductive Medicine and Biology
Purpose Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(−), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM ...
Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino   +6 more
doaj   +1 more source

Effect of Food Intake on the Pharmacokinetics of the Selective Progesterone Receptor Modulator Vilaprisan: A Randomized Clinical Study in Healthy Postmenopausal Women. [PDF]

Clin Pharmacol Drug Dev, 2021
Schultze-Mosgau MH, Kaiser A, Zollmann FS.   +2 more
europepmc   +1 more source

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

Fibroids and infertility

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The presence of uterine fibroids impacts fertility through multiple mechanisms. While subserosal fibroids have minimal impact, especially when of reduced size, the presence of intramural fibroids impacts both the likelihood of pregnancy and its outcomes.
Edgar Mocanu, Basil Tarlatzis, Dov Feldberg, Ivonne Diaz, Christina O'Brien, Nikhil Purandare   +5 more
wiley   +1 more source

Immunopharmacology of ulipristal as an emergency contraceptive

International Journal of Women's Health, 2011
Ralph P MiechDepartment of Molecular Pharmacology, Physiology and Biotechnology, Warren Alpert School of Medicine, Brown University, Providence, RI, USAAbstract: A new progesterone antagonist, ulipristal has been made available as an emergency ...
Miech RP
doaj  

Markers of Cellular Proliferation, Apoptosis, Estrogen/Progesterone Receptor Expression and Fibrosis in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids. [PDF]

J Clin Med, 2021
Szydłowska I, Grabowska M, Nawrocka-Rutkowska J, Piasecka M, Starczewski A.   +4 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source