Results 101 to 110 of about 1,752,062 (351)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Aid Selectivity According to Augmented Criteria [PDF]

A dominant trend in the literature maintains that donor assistance should be targeted to poor countries with sound institutions and policies. In this context, donor selectivity refers to what extent aid is allocated according to the principles of this ...
Jacky AMPROU, Patrick GUILLAUMONT, Sylviane GUILLAUMONT JEANNENEY   +2 more
core   +3 more sources

Glycerol Electrooxidation at Structured Nickel Electrodes and the Effect of Geometry on the Selectivity of Product

ChemElectroChem
Electrocatalytic selectivity is generally explained in terms of atomic‐scale properties, i.e., active sites, overlooking the impact of macroscopic electrode geometry and structure, which affect the macroscopic mass transport.
Ali Raza Khan, Bhawana Kumari, Jan Wegner, Filippo Pedrini, Laud Anim Adofo, André Olean‐Oliveira, Ulrich Hagemann, Stefan Kleszczynski, Corina Andronescu, Viktor Čolić   +9 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation

Molecules, 2019
The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis.
Thomas Fischer, Rainer Riedl
doaj   +1 more source

Sample Efficient Interactive End-to-End Deep Learning for Self-Driving Cars with Selective Multi-Class Safe Dataset Aggregation [PDF]

, 2019
Yunus Bicer, Ali Alizadeh, Nazim Kemal Ure, Ahmetcan Erdogan, Orkun Kizilirmak   +4 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Toxicity of organic supplies for the egg parasitoid Telenomus podisi [PDF]

Ciência Rural, 2014
Toxicity (dosage per hectare) of: 1) Baculovirus anticarsia 140x109 cpi; 2) Bacillus thuringiensis 16.8g; 3) Azadirachtin-A, azadirachtin-B, nimbina and salamina 9.6 ppm; 4) Rotenoids 4 liters; 5) Nitrogen 1.3%, phosphorus 3.0% and total organic carbon 8.
Débora Mello da Silva, Adeney de Freitas Bueno   +1 more
doaj  

Produtos naturais e sintéticos no controle de Leucoptera coffeella (Guérin-Mèneville & Perrottet, 1842) (Lepdoptera: Lyonetiidae) e seus efeitos sobre a predação por vespas Natural and sinthetic products in the control of Leucoptera coffeella (Guérin-Mèneville & Perrottet, 1842) (Lepidoptera: Lyonetiidae) and their effects on predation for wasps

Ciência e Agrotecnologia, 2006
O controle do bicho-mineiro-do-cafeeiro Leucoptera coffeella (Guérin-Mèneville & Perrottet, 1842) é realizado por meio de inseticidas de amplo espectro de ação, capazes de causar desequilíbrios biológicos, sendo importante a busca por produtos que ...
José Marcos Angélico de Mendonça, Geraldo Andrade Carvalho, Rubens José Guimarães, Paulo Rebelles Reis, Luiz Carlos Dias Rocha   +4 more
doaj   +1 more source