Results 111 to 120 of about 1,752,062 (351)

Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models [PDF]

, 2020
Hannah M. Hollandsworth, Hiroto Nishino, Michael A. Turner, Siamak Amirfakhri, Filemoni Filemoni, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet   +7 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

An Unexpected Role of Local Selectivity in Social Promotion [PDF]

A selection process and a hierarchical promotion system in a dynamic model are considered as in Harrington (1998) and Garcia-Martinez (2010), where agents are "climbing the pyramid" in a rank-order contest based on the "up or out" policy.
Garcia-Martinez, Jose A.
core   +1 more source

Insights from Selective Non-phosphinic Inhibitors of MMP-12 Tailored to Fit with an S1′ Loop Canonical Conformation [PDF]

, 2010
Laurent Devel, Sandra Garcia, Bertrand Czarny, Fabrice Beau, E. Lajeunesse, Laura Vera, Dimitris Georgiadis, E.A. Stura, Vincent Dive   +8 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Editorial: Heterogeneous Catalysis for Methane Activation

Frontiers in Chemistry, 2022
Juanjuan Liu, Shihui Zou, Yun Liu, Yun Liu, Jie Fan   +4 more
doaj   +1 more source

A function‐valued trait approach to estimating the genetic basis of size at age and its potential role in fisheries‐induced evolution

Evolutionary Applications, 2019
Natural selection is inherently a multivariate phenomenon. The selection pressure on size (natural and artificial) and the age at which selection occurs is likely to induce evolutionary changes in growth rates across the entire life history. However, the
Jin Gao, Stephan B. Munch
doaj   +1 more source

SYNTHESIS AND CHARACTERIZATION OF POLYIMIDEZEOLITE MIXED MATRIX MEMBRANE FOR BIOGAS PURIFICATION [PDF]

, 2009
Biogas has become an attractive alternative energy source due to the limitation of energy from fossil. In this study, a new type of mixed matrix membrane (MMM) consisting of polyimide-zeolite was synthesized and characterized for biogas purification ...
Budiyono, Budiyono, I.N. , Widiasa, Seno, Johari, Sunarso, Sunarso, Tutuk Joko, Kusworo   +4 more
core  

Polarization selective ultra-broadband wavelength conversion in silicon nitride waveguides

, 2022
Arman Ayan, Florent Mazeas, Junqiu Liu, Tobias J. Kippenberg, Camille-Sophie Brès   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source