Results 171 to 180 of about 17,575 (209)

Analysis of the Mouse Selenoprotein P Gene

Biological Chemistry, 1998
In vertebrates several proteins containing a covalently bound selenocysteine residue have been identified. Among these, selenoprotein P is the most unusual one: depending on the species, 8-12 selenocysteine residues are cotranslationally integrated into the polypeptide chain. The protein was traced in rat plasma, but its role has not been worked out so
P, Steinert, D, Bächner, L, Flohé
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Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity

Metallomics, 2013
Aggregation and cytotoxicity of the amyloid-β (Aβ) peptide with transition metal ions in neuronal cells have been suggested to be involved in the progression of Alzheimer's disease (AD). A therapeutic strategy to combat this incurable disease is to design chemical agents to target metal-Aβ species.
Xiubo, Du, Haiping, Li, Zhi, Wang, Shi, Qiu, Qiong, Liu, Jiazuan, Ni   +5 more
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Rat plasma selenoprotein P properties and purification

Biochimica et Biophysica Acta (BBA) - General Subjects, 1989
A selenoprotein in rat plasma, selenoprotein P, was fractionated and characterized. Plasma collected from rats 3 h post injection of 75SeO3(2-) contained one 75Se-labeled protein, selenoprotein P. Selenoprotein P was fractionated using salt precipitation, Affi-Gel Blue, and DEAE chromatography.
P A, Motchnik, A L, Tappel
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Purification of selenoprotein P from human plasma

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994
Selenoprotein P was partially purified (> 1000-fold) from human plasma in four chromatographic steps using 75Se-labeled selenoprotein P secreted by HepG2 cells in culture as a marker. The purified preparation was injected into mice and monoclonal antibodies, which precipitated the labeled protein, were generated.
B, Akesson, T, Bellew, R F, Burk
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Selenoprotein P: Properties, Functions, and Regulation

Archives of Biochemistry and Biophysics, 2000
Selenoprotein P (SeP) is a plasma protein which contains 10 selenocysteine residues per polypeptide. It accounts for more than 50% of the selenium content in rat and human plasma but its function is still not completely understood. However, a function as an extracellular antioxidant seems most probable.
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Selenoprotein P. A Selenium-Rich Extracellular Glycoprotein

The Journal of Nutrition, 1994
Selenoprotein P is a glycoprotein that has been purified from rat and human plasma. In selenium-replete rats it contains 65% of the plasma selenium and its concentration is 25-30 mg protein/L. In selenium-deficient rats its concentration is < 3 mg protein/L.
R F, Burk, K E, Hill
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Multiple Forms of Selenoprotein P in Rat Plasma

Archives of Biochemistry and Biophysics, 1996
SDS-PAGE of immunoaffinity-purified rat seleno-protein P demonstrates a major band at 57 kDa and a less intense band at 45 kDa, suggesting the existence of more than one form of the protein. Separate experiments were carried out in which plasma from rats administered 75Se and immunoaffinity-purified 75Se-labeled selenoprotein P were applied to a ...
H S, Chittum, S, Himeno, K E, Hill, R F, Burk   +3 more
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Binding of plasma selenoprotein P to cell membranes

Journal of Inorganic Biochemistry, 1993
Competitive binding assays were performed to determine the amount of binding of 75Se-labeled plasma selenoprotein P (PSP) to membranes from different rat tissues at physiologic pH. 75Se PSP for use as a ligand in the binding assays was labeled in vivo by injecting rats with 75Se selenious acid.
D S, Wilson, A L, Tappel
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Equimolar Hg-Se Complex Binds to Selenoprotein P

Biochemical and Biophysical Research Communications, 1997
Binding of equimolar mercury (Hg) and selenium (Se) to a specific plasma protein in the detoxification of Hg was studied in vitro by the HPLC/inductively coupled argon plasma-mass spectrometry (ICP-MS) method with use of an enriched stable isotope.
S, Yoneda, K T, Suzuki
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Selenoprotein P in Patients on Home Parenteral Nutrition

Journal of Parenteral and Enteral Nutrition, 1996
Background: The purpose of this study was to evaluate the use of selenoprotein P as an indicator of selenium status in patients receiving home parenteral nutrition. Methods: Adult patients (n = 38) who had been on parenteral nutrition with no addition of selenium for 3 to 216 months were included in the study. Plasma samples were analyzed for selenium,
T, Rannem, M, Persson-Moschos, W, Huang, M, Staun, B, Akesson   +4 more
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