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Selenoprotein P – die Drehscheibe im Selenstoffwechsel
Zeitschrift für Orthomolekulare MedizinZusammenfassungSelen ist ein essenzielles Spurenelement, das im Körper in Form von Selenoproteinen verschiedene physiologische Funktionen erfüllt. Die Hauptform des Selens im Blutplasma ist das Selenoprotein P (SELENOP).
Günther Stoll +2 more
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Multiple selenocysteine content of selenoprotein P in rats
Journal of Inorganic Biochemistry, 1990Partially purified selenoprotein P from rat plasma was digested with either trypsin, endoprotease Lys-C, or endoprotease Arg-C and analyzed by high pressure liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis. Several 75Se-labeled peptides were detected.
P A, Motchnik, A L, Tappel
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Characteristics and Function of Selenoprotein P
2002Selenoprotein P has several characteristics that may be clues to its function. It contains many selenium atoms and therefore probably has a redox function. It binds heparin in a pH-dependent manner that would predict its attraction to areas of inflammation where pH is low. It is associated with endothelial cells which produce nitric oxide.
Raymond F. Burk, Kristina E. Hill
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Selenoprotein P Protects Low-density Lipoprotein Against Oxidation
Free Radical Research, 2004Selenoprotein P (SeP) is an extracellular glycoprotein with 8-10 selenocysteines per molecule, containing approximately 50% of total selenium in human serum. An antioxidant function of SeP has been postulated. In the present study, we show that SeP protects low-density lipoproteins (LDL) against oxidation in a cell-free in-vitro system.
Henrik, Traulsen +4 more
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Conserved features of selenoprotein P cDNA
Biochemical Society Transactions, 1993K E, Hill, R S, Lloyd, R F, Burk
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L-Serin als Selenoprotein-P-Aktivator
Zeitschrift für Orthomolekulare MedizinZusammenfassungDie Aminosäure L-Serin ist essenziell für Selenoproteine, insbesondere von Selenoprotein P. Üblicherweise transportiert Transfer-RNA (tRNA) Aminosäuren zum Ribosom, wo sie die Translation der mRNA in Polypeptide ermöglicht. Bei Selenoproteinen ist das etwas anders.
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