Results 61 to 70 of about 5,133,612 (224)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Resilience revisited: a systematic review and synthesis of Non-Suicidal Self-Injury (NSSI) and its relation with resilience

BMC Psychiatry
Background The aim of the current study is to examine the relationship between nonsuicidal self-injury (NSSI) and resilience. Resilience has been identified as a critical area for further investigation in the context of NSSI.
Daphne Weedage, Nienke Kool-Goudzwaard, Dwayne Meijnckens, Robert R. J. M. Vermeiren, Cyril Boonmann   +4 more
doaj   +1 more source

Self-Harm Inventory (SHI) Versi Indonesia Sebagai Instrumen Deteksi Dini Perilaku Self-Harm

Jurnal Psikiatri Surabaya, 2020
Background: Self-harming behavior (SHB) is an iceberg phenomenon commonly occurred in both normal population and patients with mental illness. This behavior showed an increase in trend and may develop into suicidal behavior if not treated properly ...
Andrian Fajar Kusumadewi, Bambang Hastha Yoga, Sumarni Sumarni, Silas Henry Ismanto   +3 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study

PCN Reports
Aim The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self‐harm ideation (SHI) at 1 month postpartum.
Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama   +18 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Self‐Harm and Suicidal Behavior Among Prisoners in South Asia: A Narrative Review

Health Science Reports
Background and Aims Self‐harm and suicidal behavior in prison is a blind spot in South Asia. Little has been known about the estimates and associated factors in the countries.
S. M. Yasir Arafat, Sujita Kumar Kar
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Cultivating participatory processes in self‐harm app development: A case‐study and working methodology

JCPP Advances
Background Self‐harm and suicide related behaviours are increasing in young people, and clinical support is not adequately meeting needs. Improved approaches to assessment and the clinical management of self‐harm will result from codesign processes and ...
Camilla M. Babbage, Joanna Lockwood, Lily Roberts, Josimar Mendes, Chris Greenhalgh, Lucy‐Paige Willingham, Emmanuel Wokomah, Rebecca Woodcock, Petr Slovak, Ellen Townsend, the Digital Youth research team   +10 more
doaj   +1 more source

The Relationship between Self-Harm and Alexithymia

, 2015
This paper presents a systematic review of the literature concerning the relationship between alexithymia and self-harm. Fifteen studies were selected following a systematic search of relevant databases.
Norman, H., Borrill, J.
core   +1 more source