Results 111 to 120 of about 269,140 (232)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Investigation on Regularities of Self‐Healing Breakdown in Metallized Film Capacitors for AC Application

Advanced Materials Interfaces
Metallized film capacitors (MFCs) exhibit a distinctive self‐healing capability, making them particularly suitable for reactive compensation in high‐voltage power systems. However, frequent self‐healing breakdowns or failures can significantly compromise
Fei Yan, Jiao Zhou, Xiang Huang, Huiwen He, Qiaogen Zhang   +4 more
doaj   +1 more source

Electrochemical assessment of the self-healing properties of cerium doped sol-gel coatings on 304L stainless steel substrates [PDF]

, 2012
The present work aims at assessing the corrosion behavior of 304L stainless steel substrates pre-treated with 3-glicidoxypropyltrimethoxy silane (GPTMS) solutions modified with cerium nitrate or cerium oxide nanoparticles.
Adriaens, Mieke, Verbeken, Kim, Zandi Zand, Roohangiz   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Periapical Bone Healing of a Large Radicular Cyst Following Surgical Endodontic Treatment Without Regenerative Procedures: A 2.5‐Year Follow‐Up Case Report

Clinical Case Reports
This case report highlights the conservative management of a large peri‐apical lesion involving multiple teeth of the maxilla where the lesion eroded the maxilla's palatal, buccal, and nasal plates with a mobile central incisor.
Anisha Mishra, Jitendra Sharan, Anand Marya   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Protein‐Inspired Polymers with Tunable Microphase Structures toward Autonomous Self‐Healing in Aqueous Environments

Advanced Materials Interfaces
The self‐healing of polymer materials in aqueous environments remains a significant challenge. Herein, a protein‐inspired strategy for hydrophobic/hydrophilic‐induced microphase separation is proposed to construct self‐healing polymers in an aqueous ...
Yanwen Hu, Yan Song, Guo Liang Li
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Exploring Self‐Repair Capabilities of ATSP Vitrimers for Crack Mitigation in Aerospace Applications

Macromolecular Materials and Engineering
Vitrimers, although categorized as thermosetting polymers, differ from traditional ones in that their thermally induced crosslinks undergo reconfiguration through covalent bond exchanges in response to thermal stimuli.
Ajinkya Raut, Jacob L. Meyer, Mohammad Naraghi, Andreas A. Polycarpou   +3 more
doaj   +1 more source