Results 101 to 110 of about 4,752,657 (192)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Microencapsulation of reactive amines and isocyanates and their application to self-healing systems [PDF]

, 2011
Microcapsule-based self-healing systems enable repair of crack damage in polymers and polymer matrix composites. Existing self-healing chemistries are limited by relatively weak chemical bonding between the matrix and the healing material, temperature ...
McIlroy, David A.
core  

Monomer Trapping Synthesis Toward Dynamic Nanoconfinement Self‐healing Eutectogels for Strain Sensing

Advanced Science
The rapid advancement in attractive platforms such as biomedicine and human‐machine interaction has generated urgent demands for intelligent materials with high strength, flexibility, and self‐healing capabilities.
Yuesong Lv, Changchun Li, Zhangqin Yang, Mingxi Gan, Yuyan Wang, Minxun Lu, Xinxing Zhang, Li Min   +7 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Highly tough, crack‐resistant and self‐healable piezo‐ionic skin enabled by dynamic hard domains with mechanosensitive ionic channel

Smart Molecules
Robust and reliable piezo‐ionic materials that are both crack resistant and self‐healable like biological skin hold great promise for applications inflexible electronics and intelligent systems with prolonged service lives. However, such a combination of
XueBin Wang, Tong Liu, FuYao Sun, Jingyi Zhang, BoWen Yao, JianHua Xu, JiaJun Fu   +6 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

High‐Conductivity, Self‐Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human‐Machine Interactions Under Extreme Cold Conditions

Advanced Science
Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human‐machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity.
Fei Han, Shumeng Chen, Fei Wang, Mei Liu, Jiahui Li, Hao Liu, Yanshen Yang, Haoqing Zhang, Dong Liu, Rongyan He, Wentao Cao, Xiaochuan Qin, Feng Xu   +12 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source