Results 101 to 110 of about 269,140 (232)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Water‐Triggered Reconfigurable Glycerogels for Sustainable All‐Gel Supercapacitors

Advanced Science
The polymeric structures of synthetic gels are typically static, which makes them damage‐prone and nonrecyclable. Inspired by the dynamic reconfigurability of biological tissues, which eliminate old/damaged cells and regenerate new ones via biological ...
Md. Tariful Islam Mredha, Adith Varma Rama Varma, Tanish Gupta, Insu Jeon   +3 more
doaj   +1 more source

Design and development of a self-healing fuse [PDF]

Mercury-filled self-healing fuses for protecting solid state circuits from faults - design and ...
Harris, L. P., Jones, N. D.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fabrication and assessment on morphological, thermal stability and self‐healing efficiency of microcapsule‐based jute/epoxy bio‐composites

SPE Polymers
In this study, microcapsule‐based jute fiber reinforced epoxy self‐healing composites were fabricated using the vacuum bagging technique. Water‐soluble epoxy microcapsules were synthesized by the in‐situ polymerization method.
Md. Mahmudul Adil, M. S. Rabbi, Tasfia Tasnim   +2 more
doaj   +1 more source

Synthesis of mechanically strong waterborne poly(urethane-urea)s capable of self-healing at elevated temperatures [PDF]

, 2019
Although various chemistries have been introduced into polyurethanes in order to obtain self-healing abilities, implementing these materials in applications requiring high strength is challenging as strong materials imply a limited molecular motion, but ...
Asua González, José María, Ballard, Nicholas, Fernández San Martín, Mercedes, Nevejans, Sil, Reck, Bernd, Rivilla de la Cruz, Iván, Santamaría Ibarburu, Pedro Antonio   +6 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Ion‐Mediated Gelation of Thermo‐Responsive Cellulose Nanofibril/Poly(N‐isopropylacrylamide) Hybrid Hydrogels with Tunable De‐Swelling Kinetics

Macromolecular Materials and Engineering
The tunability of the lower critical solution temperature (LCST) of poly(N‐isopropylacrylamide) (PNIPAM) to lower or higher temperatures, as well as the ease of modulation of the LCST phase transition kinetics broadens the scope of application of PNIPAM ...
Bennie Motloung, Rueben Pfukwa, Bert Klumperman   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Flexible perovskite photodetector with room‐temperature self‐healing capability without external trigger

InfoMat
Flexible perovskite photodetectors (FPDs) are promising for novel wearable devices in bionics, robotics and health care. However, their performance degradation and instability during operations remain a grand challenge.
Guoyi Li, Shenghong Li, Jahangeer Ahmed, Wei Tian, Liang Li   +4 more
doaj   +1 more source