Results 91 to 100 of about 269,140 (232)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Protein‐Mediated ZnO Synthesis for Self‐Healing in Natural Rubber

Macromolecular Materials and Engineering
Natural rubber (NR) consists of mainly cis‐1,4‐polyisoprene with proteins as notable nonrubber components that significantly influence its properties. A relatively unexplored aspect is the role of these proteins in reducing and stabilizing metal ions to ...
Piriyaphron Fueangphakdee, Adun Nimpaiboon, Preeyanuch Junkong   +2 more
doaj   +1 more source

Self-healing cable for extreme environments [PDF]

, 2009
Self-healing cable apparatus and methods disclosed. The self-healing cable has a central core surrounded by an adaptive cover that can extend over the entire length of the self-healing cable or just one or more portions of the self-healing cable.
Huston, Dryver R., Tolmie, Bernard R.
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Various Methods of Encapsulation Biomaterials in Self‐Healing Concrete: A Review

Engineering Reports
Concrete is known for its inherent vulnerability to cracking, which can be attributed to factors like temperature fluctuations, changes in moisture levels, and cyclic loading.
Mostafa Adresi, Mehdi Khoshoo
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Engineering of Multi‐Dynamic Bonds Toward Room‐Temperature Self‐Healing Epoxy/MXene Adaptable Network with Record‐High Toughness

Advanced Science
Epoxy thermosets with exceptional toughness and self‐healing properties are essential for high‐end manufacturing applications and sustainable development.
Xiaobo Zhu, Yu Hao, Liang‐Feng Huang, Haichao Zhao, Liping Wang   +4 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Self‐Healing Materials from Electronically Integrated Microscopic Robots

Advanced Intelligent Systems
Biological materials heal, learn, and adapt thanks to the collective work of tiny agents acting at their microscale. Extensive research in robotics has tried to duplicate this scheme in a synthetic system, yet in their current centimeter‐scale forms, the
Lucas C. Hanson, William H. Reinhardt, Marc Z. Miskin   +2 more
doaj   +1 more source

Self-healing systems and virtual structures

, 2012
Modern networks are large, highly complex and dynamic. Add to that the mobility of the agents comprising many of these networks. It is difficult or even impossible for such systems to be managed centrally in an efficient manner. It is imperative for such
Trehan, Amitabh
core