Results 71 to 80 of about 3,708,862 (338)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Factors determining patients’ intentions to use point-of-care testing medical devices for self-monitoring: The case of international normalised ratio self-testing

, 2012
This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. - Copyright @ 2012 Dove Medical Press LtdThis article has been made available through the Brunel Open Access Publishing Fund ...
Kuljis, J, Shah, SGS, Barnett, J, Hone, K, Kaczmarski, R   +4 more
core   +1 more source

The Role of Social Support in Fostering Self-Acceptance Among Mothers of Children with Intellectual Disabilities

Jurnal Bimbingan dan Konseling Terapan
This study investigates the relationship between social support and self-acceptance among mothers of children with intellectual disabilities. Utilizing a quantitative correlational design, it examines how perceived social support impacts self-acceptance ...
Angela Oktakurnia Rahel Kristiadi, Christiana Hari Soetjiningsih   +1 more
doaj   +1 more source

The Effectiveness of Educational Intervention "Be yourself" on Negative Beliefs, Self-Acceptance, Self-Expression and Self-Esteem of 15-18-year-old Adolescents with Self-Criticism [PDF]

مطالعات روانشناختی
The aim of the study was the effectiveness of the Be-Yourself educational intervention on negative beliefs, self-acceptance, self-expression, and self-esteem of self-criticism adolescents. The research method was a quasi-experimental study with pre-test,
Faezeh Taslimi, Mansoreh Bahramipour
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Relationship of self-image and self-acceptance with the expression of anger in girls diagnosed with conduct disorder

, 2017
Objective: The aim of the study was to evaluate the structure of self-image and the level of self-acceptance in girls with conduct disorder and to determine the relationship of self-image and self-acceptance with the expression of anger.
Agnieszka Kruczek
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Motor ability and self-esteem: The mediating role of physical self-concept and perceived social acceptance [PDF]

, 2015
Objectives: One important issue in sport and exercise psychology is to determine to what extent sports and exercise can help to increase self-esteem, and what the underlying mechanism might be.
Blum, Markus, Valkanover, Stefan, Schmidt, Mirko, Conzelmann, Achim   +3 more
core   +1 more source

Life satisfaction, generalized sense of self-efficacy and acceptance of illness in rheumatoid arthritis patients depending on age and severity of the disease

, 2023
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by periods of exacerbation (physical limitations, depressed mood, depressive states and decreased life satisfaction) and remission (hope of health improvement).
Staszkiewicz, Magdalena, Kulesa-Mrowiecka, Małgorzata, Małgorzata Kulesa-Mrowiecka, Jaworek, Jolanta, Jolanta Jaworek, Szklarczyk, Joanna, Magdalena Staszkiewicz, Joanna Szklarczyk   +7 more
core   +1 more source