Results 81 to 90 of about 3,708,862 (338)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Acceptance and mindfulness-based stress management for support staff caring for individuals with intellectual disabilities [PDF]
, 2014 Support staff working with individuals with intellectual disability (ID) and challenging behaviour experience high levels of work-related stress. Preliminary theoretical and experimental research has highlighted the potential suitability of acceptance ...
Morris, Paul Graham; id_orcid +6 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
“Very Misunderstood”: Self-Perceived Social Communication Experiences of Autistic Young Adults
YouthHistorically, society has labeled social communication differences in autistic individuals as disordered by comparing them to the social communication behaviors of the predominant non-autistic population.
Aieshea L. Banks +3 more
doaj +1 more source
Subjective well-being and self acceptance.
The Japanese journal of psychology, 1998 The purpose of the present study was to examine the relationship between subjective well-being and self acceptance, and to design a happiness self-writing program to increase self acceptance and subjective well-being of adolescents. In study 1, we examined the relationship between social interaction and self acceptance.
Makino, Yumiko, Tagami, Fujio
openaire +3 more sources
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
, 2008 oai:eprints.gold.ac.uk:2In a test of two key features of REBT, causal relationships between irrational beliefs and unconditional self-acceptance were experimentally investigated in a sample of 106 non-clinical participants using a priming technique ...
Davies, Martin F.
core
The body self and the frequency, intensity and acceptance of menopausal symptoms
, 2015 Introduction: There are many studies on the concept of body image (usually understood narrowly as body acceptance) in menopausal women, but relationships between the body self and menopausal symptoms have not been explored yet.
Jowita Wycisk, Olga Sakson-Obada
core +1 more source