Results 91 to 100 of about 7,366,469 (392)

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ukrainian Post-Communist Transformation: Causes, Consequences and Threats

Quaestiones Geographicae, 2014
The post-communist transformation of Ukraine differs significantly from that of other countries of Central and Eastern Europe. First of all, Ukraine’s transition from totalitarianism to democracy has been long and still remains uncompleted.
Kuczabski Aleksander, Michalski Tomasz
doaj   +1 more source

The interplay between the hippocampus and the amygdala in regulating aberrant hippocampal neurogenesis during protracted abstinence from alcohol dependence

Frontiers in Psychiatry, 2013
The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. Particularly interesting is the recent accumulating evidence that sensitized extrahypothalamic stress ...
Chitra D Mandyam
doaj   +1 more source

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats [PDF]

, 2019
Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards)
Duan, Ying, Jiang, Feng-Ze, Jin, Su-Bo, Li, Ming, Liang, Jing, Shen, Fang, Sui, Nan, Zhang, Jian-Jun, Zheng, Wei   +8 more
core   +1 more source

Nicotine Increases Alcohol Intake in Adolescent Male Rats [PDF]

, 2017
Background: Use of alcohol and tobacco, the two most concurrently abused drugs, typically first occurs during adolescence. Yet, there have been no systematic analyses of ethanol (EtOH) and nicotine (Nic) interactions during adolescence.
Armando Lárraga, Frances M. Leslie, James D. Belluzzi   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Assessment of medication self-administration using artificial intelligence

Nature Medicine, 2021
Mingmin Zhao, Kreshnik Hoti, Hao Wang, Aniruddh Raghu, D. Katabi   +4 more
semanticscholar   +1 more source

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors

Journal of Neuroscience, 2015
Pain management in opioid abusers engenders ethical and practical difficulties for clinicians, often resulting in pain mismanagement. Although chronic opioid administration may alter pain states, the presence of pain itself may alter the propensity to ...
L. Hipólito, Adrianne R. Wilson-Poe, Y. Campos-Jurado, Elaine Zhong, J. González-Romero, L. Virág, R. Whittington, S. Comer, S. Carlton, B. Walker, M. Bruchas, Jose A. Morón   +11 more
semanticscholar   +1 more source