Results 81 to 90 of about 7,196,003 (316)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Body image and self-concept in adolescent girls

, 2006
Anorexia Nervosa has been recently recognized as one of the most common chronic illnesses that affects the female adolescent population today. Although there has been an abundance of research into eating disorders in a variety of fields, significant ...
Halse, Christine, Ha, My Trinh, Marsh, Herbert W., Martin, Andrew J.   +3 more
core  

Introduction to pharmacology, and routes of drugs administration and absorption [PDF]

, 2017
This eChapter has an introduction to pharmacology and drug nomenclature followed by a detailed discussion of routes of administration starting with oral administration (with absorption from the gastrointestinal tract, and first pass liver metabolism ...
Doggrell, Sheila
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations

Frontiers in Psychiatry
ObjectiveThis study investigates the reinforcing effects and monoamine oxidase-A (MAO-A) inhibitory properties of heated tobacco products (HTPs), comparing them to nicotine alone. It also examines brand-specific differences in MAO-A inhibition to provide
Xiangyu Li, Xiangyu Li, Zheng Ding, Zheng Ding, Xingyi Jiang, Xingyi Jiang, Hongjuan Wang, Hongjuan Wang, Yanbo Luo, Yanbo Luo, Huan Chen, Huan Chen, Yongqiang Pang, Yongqiang Pang, Hongwei Hou, Hongwei Hou, Qingyuan Hu, Qingyuan Hu   +17 more
doaj   +1 more source

Is it stress? The role of stress related systems in chronic food restriction-induced augmentation of heroin seeking in the rat

Frontiers in Neuroscience, 2013
Drug addiction is a chronic disease characterized by recurring episodes of abstinence and relapse. The precise mechanisms underlying this pattern are yet to be elucidated, but stress is thought to be a major factor in relapse.
Firas eSedki, Zarish eAbbas, Staci eAngelis, Jeffrey eMartin, Tracey eD'Cunha, Uri eShalev   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Self-administration of medication in hospital: patients' perspectives

, 2004
Background. Little information is available about patients' perspectives on self- or nurse-related administration of medication.Aim. The aim of the study was to determine patients' perspectives about self-medication in the acute care setting.Methods.
Linda Baker (13055274), Elizabeth Manias (13068882), C Beanland (13284930), Robin Riley (13050957)   +3 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL SELF-ADMINISTRATION BY SPRAGUE-DAWLEY RATS AND STIMULATION OF IN VIVO DOPAMINE TRANSMISSION IN THE NUCLEUS ACCUMBENS SHELL

Frontiers in Psychiatry, 2014
2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from 2-arachidonate-containing phosphoinositides by the action of diacyglycerol lipase in response to increased ...
Maria Antonietta eDe Luca, Maria Antonietta eDe Luca, Valentina eValentini, Valentina eValentini, Zisis eBimpisidis, Fabio eCacciapaglia, Pierluigi eCaboni, Gaetano eDi Chiara, Gaetano eDi Chiara, Gaetano eDi Chiara   +9 more
doaj   +1 more source