Results 61 to 70 of about 977,715 (316)

The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

Frontiers in Behavioral Neuroscience, 2016
Social partners influence the likelihood of using drugs, developing a substance use disorder, and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of ...
Mark Andrew Smith, Huailin Zhang, Andrea Maureen Robinson   +2 more
doaj   +1 more source

STIMULUS CONTROL OF COCAINE SELF‐ADMINISTRATION [PDF]

Journal of the Experimental Analysis of Behavior, 2003
Environmental stimuli that set the occasion wherein drugs are acquired can “trigger” drug‐related behavior. Investigating the stimulus control of drug self‐administration in laboratory animals should help us better understand this aspect of human drug abuse.
Stanley J, Weiss, David N, Kearns, Scott I, Cohn, Charles W, Schindler, Leigh V, Panlilio   +4 more
openaire   +2 more sources

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
core  

Glutamatergic Plasticity in Medial Prefrontal Cortex and Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration [PDF]

, 2011
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the molecular and behavioral plasticity associated with addiction to drugs of abuse.
Ghasemzadeh, Behnam, Giles, Chad, Mantsch, John R., Purgianto, Anthony, Seubert, Chad, Vasudevan, Preethi   +5 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Involvement of the Cuneate Nucleus in the Acupuncture Inhibition of Drug-Seeking Behaviors

Frontiers in Neuroscience, 2019
Our previous studies have shown that acupuncture suppresses addictive behaviors induced by drugs of abuse, including cocaine, morphine and ethanol, by modulating GABA neurons in the ventral tegmental area (VTA) and dopamine (DA) release in the nucleus ...
Suchan Chang, Yeonhee Ryu, Yu Fan, Se Kyun Bang, Se Kyun Bang, Nam Jun Kim, Jin Gyeom Lee, Jin Mook Kim, Bong Hyo Lee, Chae Ha Yang, Hee Young Kim   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats

Frontiers in Behavioral Neuroscience, 2018
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression.
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Walter Fratta, Liana Fattore, Liana Fattore   +6 more
doaj   +1 more source

Increased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration [PDF]

, 2009
In humans, cocaine use has long been associated with poor attentional control and decreased efficiency in goal-oriented behavior. Animal models of these stereotypic drug effects, however, have thus far failed to produce quantifiable data sets in part ...
Olsen, Adam
core  

Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction [PDF]

, 2016
The nociceptin (NOP) receptor is a G-protein-coupled receptor whose natural ligand is the nociceptin/orphanin FQ (N/OFQ) peptide. Evidence from pharmacological studies suggests that the N/OFQ system is implicated in the regulation of several addiction ...
A Kuzmin, A Post, A Rizzi, A Rizzi, AC Hansson, B Spagnolo, C Mollereau, D Economidou, D Economidou, D Economidou, EC Gavioli, F Jenck, FM Dautzenberg, Friedbert Weiss, G de Guglielmo, G de Guglielmo, GC Sartor, Giordano de Guglielmo, Girolamo Calò, Giulia Scuppa, H Aujla, H Zhang, J Huang, J Kotlinska, JA Briant, JC Meunier, JM Witkin, JR Homberg, JR Walker, K Rutten, K Rutten, K Sakoori, K Sakoori, K Sakoori, Linda M Rorick-Kehn, LM Rorick-Kehn, M Corbani, M Kallupi, M Kallupi, MA Statnick, MA Toledo, Marsida Kallupi, Michael A Statnick, NR Richardson, NT Zaveri, P Marquez, P Marquez, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, RJ Zhao, RK Reinscheid, RL Pennock, Roberto Ciccocioppo, S Semenova, S Spampinato, T Darland, VA Holanda, X Xuei   +60 more
core   +2 more sources