Results 91 to 100 of about 977,715 (316)

Histamine H3 receptor: A novel therapeutic target in alcohol dependence?

Frontiers in Systems Neuroscience, 2012
The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in ...
Pertti ePanula, Saara eNuutinen, Jenni eVanhanen, Tiia eMäki   +3 more
doaj   +1 more source

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats [PDF]

\ud RATIONALE:\ud \ud Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking.
Jemma K. Richards, Jeffrey A. Simms, Pia Steensland, Sharif A. Taha, Stephanie L. Borgland, Antonello Bonci, Selena E. Bartlett   +6 more
core   +2 more sources

Serotonin-3 Receptors in the Posterior Ventral Tegmental Area Regulate Ethanol Self-Administration of Alcohol-Preferring (P) Rats [PDF]

, 2010
Several studies indicated the involvement of serotonin-3 (5-HT 3 ) receptors in regulating alcohol- drinking behavior. The objective of this study was to determine the involvement of 5-HT 3 receptors within the ventral tegmental area (VTA) in ...
Beardsley, Campbell, Carboni, Ding, Ding, Fadda, Ford, Gatto, Herve, Hodge, Hodge, Hodge, Ikemoto, Ikemoto, Ikemoto, Ikemoto, James M. Murphy, Jamie E. Toalston, Katner, Klein, Knapp, Koob, Liu, Liu, Lovinger, McKinzie, McKinzie, Minabe, Nowak, Nowak, Paxinos, Prisco, Rasmussen, Richard L. Bell, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Scott M. Oster, Sung, Svensson, Toalston, Tomkins, Tylene J. Pommer, Van Bockstaele, William J. McBride, Wozniak, Zachary A. Rodd   +52 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Disruption of long-term alcohol-related memory reconsolidation: Role of β-adrenoceptors and NMDA receptors

Frontiers in Behavioral Neuroscience, 2010
Disrupting reconsolidation of drug-related memories may be effective in reducing the incidence of relapse. In the current study we examine whether alcohol- related memories are prone to disruption by the β -adrenergicreceptor antagonist propranolol (
Jelte A Wouda, Leontien Diergaarde, Danai Riga, Yvar Van Mourik, Anton N M Schoffelmeer, Taco J De Vries   +5 more
doaj   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Astrocyte Ca2+ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking

Frontiers in Cellular Neuroscience
Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca2+.
Navid S. Tavakoli, Samantha G. Malone, Tanner L. Anderson, Ryson E. Neeley, Artin Asadipooya, Michael T. Bardo, Pavel I. Ortinski   +6 more
doaj   +1 more source

Drug Predictive Cues Activate Aversion-Sensitive Striatal Neurons That Encode Drug Seeking [PDF]

, 2015
Drug-associated cues have profound effects on an addict’s emotional state and drug-seeking behavior. Although this influence must involve the motivational neural system that initiates and encodes the drug-seeking act, surprisingly little is known about ...
Dupont, Matthew J., Ebben, Amanda L., Hebron, Emily M., Robble, Mykel A., Wheeler, Daniel S., Wheeler, Robert A   +5 more
core   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source