Results 101 to 110 of about 977,715 (316)

Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use and compulsive smoking

Frontiers in Psychiatry, 2013
Much evidence indicates that individuals use tobacco primarily to experience the psychopharmacological properties of nicotine and that a large proportion of smokers eventually become dependent on nicotine.
Ami eCohen, Olivier eGeorge
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Stressor- and Corticotropin releasing Factor-induced Reinstatement and Active Stress-related Behavioral Responses are Augmented Following Long-access Cocaine Self-administration by Rats [PDF]

, 2008
Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing
AM Basso, B Costall, B Costall, B Lee, B Wang, B Wang, BA Sorg, BA Sorg, CJ Sanchez, David A. Baker, David M. Francis, DJ Lodge, EB Souza De, EP Zorrilla, Eric S. Katz, G Paxinos, HC Fox, J Liu, John R. Mantsch, Joseph P. Serge, JR Mantsch, JR Mantsch, K McFarland, L Lu, L Lu, LJMJ Vanderschuren, LM Najavits, LW Swanson, MA Sutton, MA Ungless, Michael A. Hoks, N Capriles, NE Goeders, NE Goeders, NH Mutschler, PW Kalivas, PW Kalivas, R Sinha, R Sinha, RA Fuchs, RE Sorge, RM Richter, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Pellow, S Pollandt, SH Ahmed, SH Ahmed, SH Ahmed, SH Ahmed, TE Kippin, TM Korotkova, V Deroche-Gamonet, Y Shaham, Y Zhou, Z Sarnyai, Z Sarnyai   +62 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder [PDF]

, 2017
Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction.
Durand, A., Girardeau, P., Gutkin, B., Keramati, M., Serge, A.   +4 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]

, 2019
Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Newman, Amy H, Sedighim, Sharona   +4 more
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Patient And Nurse Experience Of Using Somatostatin Analogues To Treat Gastroenteropancreatic Neuroendocrine Tumors: Results Of The Somatostatin Treatment Experience Trial (STREET)

Patient Preference and Adherence, 2019
Torbjörn Ström,1 Gordana Kozlovacki,2 Peter Myrenfors,1 Martin Almquist3 1Medical Department, Ipsen AB, Stockholm, Sweden; 2Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden; 3Department of ...
Ström T, Kozlovacki G, Myrenfors P, Almquist M   +3 more
doaj  

New Patient-Centric Approaches to the Management of Alpha-1 Antitrypsin Deficiency

International Journal of COPD, 2020
Joanna Chorostowska-Wynimko,1 Miriam Barrecheguren,2 Ilaria Ferrarotti,3 Timm Greulich,4 Robert A Sandhaus,5 Michael Campos6 1Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland ...
Chorostowska-Wynimko J, Barrecheguren M, Ferrarotti I, Greulich T, Sandhaus RA, Campos M   +5 more
doaj