Results 111 to 120 of about 7,267,221 (342)

Histamine H3 receptor: A novel therapeutic target in alcohol dependence?

Frontiers in Systems Neuroscience, 2012
The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in ...
Pertti ePanula, Saara eNuutinen, Jenni eVanhanen, Tiia eMäki   +3 more
doaj   +1 more source

Nicotine is more addictive, not more cognitively therapeutic in a neurodevelopmental model of schizophrenia produced by neonatal ventral hippocampal lesions [PDF]

, 2013
Nicotine dependence is the leading cause of death in the United States. However, research on high rates of nicotine use in mental illness has primarily explained this co-morbidity as reflecting nicotine's therapeutic benefits, especially for cognitive ...
Berg, Sarah A., Chambers, R. Andrew, Cooley, Benjamin S., Engleman, Eric A., Sentir, Alena M.   +4 more
core   +1 more source

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

Frontiers in Neuroscience, 2014
To examine the role of orexin-1 and orexin-2 receptor activity on ethanol self-administration, compounds that differentially target orexin (OX) receptor subtypes were assessed in various self-administration paradigms using high-drinking rodent models ...
Rachel I. Anderson, H. Becker, B. Adams, C. Jesudason, L. Rorick‐Kehn   +4 more
semanticscholar   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: a preliminary study

Frontiers in Psychiatry, 2012
Background: Human cocaine abuse is associated with alterations in white matter integrity revealed upon brain imaging, an observation that is recapitulated in an animal model of continuous cocaine exposure.
David Andrew Nielsen, Wen eHuang, Sara C. Hamon, Lorena eMaili, Brian M. Witkin, Robert G. Fox, Kathryn A. Cunningham, F. Gerard Moeller   +7 more
doaj   +1 more source

mRNA and microRNA analysis reveals modulation of biochemical pathways related to addiction in the ventral tegmental area of methamphetamine self-administering rats [PDF]

, 2015
Background Methamphetamine is a highly addictive central nervous system stimulant with increasing levels of abuse worldwide. Alterations to mRNA and miRNA expression within the mesolimbic system can affect addiction-like behaviors and thus play a role in
Benton, Miles, Bosch, P., Kivell, Bronwyn, Macartney-Coxson, Donia   +3 more
core   +4 more sources

Social Stress and CRF–Dopamine Interactions in the VTA: Role in Long-Term Escalation of Cocaine Self-Administration

Journal of Neuroscience, 2014
The nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable interest. Intermittent social defeat stress induces both locomotor and dopaminergic cross-sensitization to cocaine, as well as escalated cocaine ...
C. O. Boyson, Elizabeth N. Holly, A. Shimamoto, L. Albrechet-Souza, L. Weiner, J. Debold, K. Miczek   +6 more
semanticscholar   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Patient And Nurse Experience Of Using Somatostatin Analogues To Treat Gastroenteropancreatic Neuroendocrine Tumors: Results Of The Somatostatin Treatment Experience Trial (STREET)

Patient Preference and Adherence, 2019
Torbjörn Ström,1 Gordana Kozlovacki,2 Peter Myrenfors,1 Martin Almquist3 1Medical Department, Ipsen AB, Stockholm, Sweden; 2Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden; 3Department of ...
Ström T, Kozlovacki G, Myrenfors P, Almquist M   +3 more
doaj