Results 111 to 120 of about 7,366,469 (392)

Disruption of long-term alcohol-related memory reconsolidation: Role of β-adrenoceptors and NMDA receptors

Frontiers in Behavioral Neuroscience, 2010
Disrupting reconsolidation of drug-related memories may be effective in reducing the incidence of relapse. In the current study we examine whether alcohol- related memories are prone to disruption by the β -adrenergicreceptor antagonist propranolol (
Jelte A Wouda, Leontien Diergaarde, Danai Riga, Yvar Van Mourik, Anton N M Schoffelmeer, Taco J De Vries   +5 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Glutamatergic Mechanisms of Comorbidity Between Acute Stress and Cocaine Self-administration

Molecular Psychiatry, 2015
There is substantial comorbidity between stress disorders and substance use disorders (SUDs), and acute stress augments the locomotor stimulant effect of cocaine in animal models. Here we endeavor to understand the neural underpinnings of comorbid stress
Constanza Garcia-Keller, Y. Kupchik, C. Gipson, Robyn M Brown, S. Spencer, F. Bollati, M. A. Esparza, Douglas Roberts-Wolfe, Jasper A. Heinsbroek, Ana-Clara Bobadilla, L. Cancela, P. Kalivas   +11 more
semanticscholar   +1 more source

Patient And Nurse Experience Of Using Somatostatin Analogues To Treat Gastroenteropancreatic Neuroendocrine Tumors: Results Of The Somatostatin Treatment Experience Trial (STREET)

Patient Preference and Adherence, 2019
Torbjörn Ström,1 Gordana Kozlovacki,2 Peter Myrenfors,1 Martin Almquist3 1Medical Department, Ipsen AB, Stockholm, Sweden; 2Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden; 3Department of ...
Ström T, Kozlovacki G, Myrenfors P, Almquist M   +3 more
doaj  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Treatment of HAE Attacks in the Icatibant Outcome Survey: An Analysis of Icatibant Self-Administration versus Administration by Health Care Professionals

International Archives of Allergy and Immunology, 2015
Background: Icatibant, a selective bradykinin B2 receptor antagonist for the treatment of acute hereditary angio-oedema (HAE) attacks in adults, can be administered by health care professionals (HCPs) or self-administered.
D. Hernández Fernández de Rojas, Ethel Ibáñez, H. Longhurst, M. Maurer, V. Fabien, W. Aberer, L. Bouillet, A. Zanichelli, T. Caballero   +8 more
semanticscholar   +1 more source

Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use and compulsive smoking

Frontiers in Psychiatry, 2013
Much evidence indicates that individuals use tobacco primarily to experience the psychopharmacological properties of nicotine and that a large proportion of smokers eventually become dependent on nicotine.
Ami eCohen, Olivier eGeorge
doaj   +1 more source

Nicotine is more addictive, not more cognitively therapeutic in a neurodevelopmental model of schizophrenia produced by neonatal ventral hippocampal lesions [PDF]

, 2013
Nicotine dependence is the leading cause of death in the United States. However, research on high rates of nicotine use in mental illness has primarily explained this co-morbidity as reflecting nicotine's therapeutic benefits, especially for cognitive ...
Berg, Sarah A., Chambers, R. Andrew, Cooley, Benjamin S., Engleman, Eric A., Sentir, Alena M.   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

New Patient-Centric Approaches to the Management of Alpha-1 Antitrypsin Deficiency

International Journal of COPD, 2020
Joanna Chorostowska-Wynimko,1 Miriam Barrecheguren,2 Ilaria Ferrarotti,3 Timm Greulich,4 Robert A Sandhaus,5 Michael Campos6 1Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland ...
Chorostowska-Wynimko J, Barrecheguren M, Ferrarotti I, Greulich T, Sandhaus RA, Campos M   +5 more
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