Results 11 to 20 of about 7,366,469 (392)

Cannabidiol inhibits sucrose self‐administration by CB1 and CB2 receptor mechanisms in rodents

open access: greenAddiction Biology, 2019
A growing number of studies suggest therapeutic applications of cannabidiol (CBD), a recently U.S. Food and Drug Administration (FDA)–approved medication for epilepsy, in treatment of many other neuropsychological disorders.
Guo‐Hua Bi   +3 more
openalex   +3 more sources

Fentanyl vapor self-administration model in mice to study opioid addiction

open access: yesScience Advances, 2020
Fentanyl vapor self-administration in mice provides a novel and noninvasive model to study opioid addiction. Intravenous drug self-administration is considered the “gold standard” model to investigate the neurobiology of drug addiction in rodents ...
Khaled Moussawi   +9 more
semanticscholar   +1 more source

Exceptional Repositioning of Dog Dewormer: Fenbendazole Fever

open access: yesCurrent Issues in Molecular Biology, 2022
Fenbendazole (FZ) is a benzimidazole carbamate drug with broad-spectrum antiparasitic activity in humans and animals. The mechanism of action of FZ is associated with microtubular polymerization inhibition and glucose uptake blockade resulting in reduced
Tania Sultana   +4 more
doaj   +1 more source

Factors contributing to municipal splits in Slovenia

open access: yesMiscellanea Geographica: Regional Studies on Development, 2020
Slovenian communities were eager to re-establish autonomous local governments after the introduction of democracy. These newly established municipalities corresponded territorially to the previous regime’s local communities; however, only 194 ...
Brajnik Irena Bačlija, Lavtar Roman
doaj   +1 more source

Ethical and political dilemmas of local self-government in Poland in the course of systemic transformations (1990–2018)

open access: yesAnnales Etyka w Życiu Gospodarczym, 2018
The study presents critical reflections on the course and results of Polish local self-government reforms from March 1990, when after 40 years of the system of territorial soviets (national councils), self-government was reintroduced into communes, until
Michał Kasiński
doaj   +1 more source

Effects of repeated binge intake of the pyrovalerone cathinone derivative 3,4-methylenedioxypyrovalerone on prefrontal cytokine levels in rats – a preliminary study

open access: yesFrontiers in Behavioral Neuroscience, 2023
Drugs of abuse activate neuroimmune signaling in addiction-related regions of the brain, including the prefrontal cortex (PFC) which mediates executive control, attention, and behavioral inhibition.
Erin K. Nagy   +6 more
doaj   +1 more source

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]

open access: yes, 2015
This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic   +5 more
core   +1 more source

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]

open access: yes, 2019
Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II   +3 more
core   +2 more sources

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

open access: yes, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M.   +3 more
core   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

open access: yes, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua   +9 more
core   +2 more sources

Home - About - Disclaimer - Privacy