Results 21 to 30 of about 5,219,296 (317)

Detrimental Effects of a Retrieval-Extinction Procedure on Nicotine Seeking, but Not Cocaine Seeking

open access: yesFrontiers in Behavioral Neuroscience, 2019
Retrieval-extinction memory reactivation procedures have been used to prevent the return of learned fear and drug seeking in preclinical models. These procedures first reactivate the original memory with a brief cue exposure (i.e., retrieval) session ...
Roeland F. Struik   +3 more
doaj   +1 more source

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

open access: yesFrontiers in Molecular Neuroscience, 2022
The persistence of drug memory contributes to relapse to drug seeking. The association between repeated drug exposure and drug-related cues leads to cravings triggered by drug-paired cues.
Shuyi Qian   +4 more
doaj   +1 more source

Histamine H3 receptor: A novel therapeutic target in alcohol dependence?

open access: yesFrontiers in Systems Neuroscience, 2012
The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in ...
Pertti ePanula   +3 more
doaj   +1 more source

Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats

open access: yesFrontiers in Behavioral Neuroscience, 2021
Alcohol use disorder (AUD) is a chronic, relapsing disorder whose genetic and environmental susceptibility components are not fully understood. Neuropeptidergic signaling has been repeatedly implicated in modulating excessive alcohol drinking, especially
Margaret A. Minnig   +4 more
doaj   +1 more source

Disruption of long-term alcohol-related memory reconsolidation: Role of β-adrenoceptors and NMDA receptors

open access: yesFrontiers in Behavioral Neuroscience, 2010
Disrupting reconsolidation of drug-related memories may be effective in reducing the incidence of relapse. In the current study we examine whether alcohol- related memories are prone to disruption by the β -adrenergicreceptor antagonist propranolol (
Jelte A Wouda   +5 more
doaj   +1 more source

Compliance of the regulation of supervision over local government in the Polish Constitution and in legal acts

open access: yesКонституційно-правові академічні студії
The aim of the article will be to analyze the regulation of supervision over local government in the Polish Constitution and in the legal system regulating the supervision of local government.
Kazimierz Bandarzewski
doaj   +1 more source

Disaster Risk Reduction for Sustainable Development Goals [PDF]

open access: yesEuropean Project Management Journal, 2017
Our civilization is witnessing the devastating power of natural disasters all over the world. Unfortunately, it is evident that the number and intensity of disasters increased over time. Consequently, grate number of victims and material damage force the
Nataša Petrović   +2 more
doaj  

Self-administration of gender-affirming hormones: a systematic review of effectiveness, cost, and values and preferences of end-users and health workers

open access: yesSexual and Reproductive Health Matters, 2022
Self-administration of quality gender-affirming hormones is one approach to expanding access to hormone therapy for individuals seeking secondary sex characteristics more aligned with their gender identity or expression and can be empowering when ...
Caitlin E. Kennedy   +6 more
doaj   +1 more source

Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists [PDF]

open access: yesNeuropsychopharmacology, 2012
Sigma(1) receptors (σ(1)Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ(1)R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course of 28 experimental sessions, which was ...
Takato, Hiranita   +4 more
openaire   +2 more sources

Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use and compulsive smoking

open access: yesFrontiers in Psychiatry, 2013
Much evidence indicates that individuals use tobacco primarily to experience the psychopharmacological properties of nicotine and that a large proportion of smokers eventually become dependent on nicotine.
Ami eCohen, Olivier eGeorge
doaj   +1 more source

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