Results 21 to 30 of about 977,715 (316)

Are cocaine-seeking “habits” necessary for the development of addiction-like behavior in rats? [PDF]

, 2018
Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and over to procure and take drugs.
Fadanelli, Monica, Kawa, Alex B., Robinson, Terry E., Singer, Bryan F.   +3 more
core   +2 more sources

Generation Z in Search of Leadership - Model of Intergenerational Leadership for Creating Commitment (MILCC) [PDF]

Cross-Cultural Management Journal
Generation Z is integrating into the fast-changing work world. The effects of its entry are rapid employee turnover, perceptions of no commitment to organizations, and difficulty in understanding employee needs. This article presents a model for creating
Tidhar LEV
doaj   +1 more source

Reinforcing Effects of the Synthetic Cathinone α-Pyrrolidinopropiophenone (α-PPP) in a Repeated Extended Access Binge Paradigm

Frontiers in Psychiatry, 2020
Synthetic cathinones are designer psychostimulants that are derivatives of the natural alkaloid cathinone, and produce effects similar to more traditional illicit stimulants such as cocaine and methamphetamine.
Erin K. Nagy, Paula F. Overby, M. Foster Olive   +2 more
doaj   +1 more source

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking [PDF]

, 2014
Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine.
A Agrawal, AC Barrett, B. Halbout, C Schwarzer, C. I. Dixon, CI Dixon, CI Dixon, CI Dixon, D. N. Stephens, DM Dick, DM Thompson, EM Weerts, G Brown, HC Fox, HJ Edenberg, HN Katz, HV Morris, HV Morris, J Covault, J Merrer Le, JD Salamone, JR Taylor, K Low, KL Conrad, LA Knackstedt, LJ Herberg, LM Reynolds, LO Bauer, M Filip, M Filip, MA Enoch, MA Enoch, MJ Thomas, ND Volkow, P Waelti, PA Broderick, PA Lind, R Keiflin, R Sinha, RA Wise, RW Keller Jr, S Erb, S Pirker, S Taverna, S Villafuerte, S. L. King, SA Kushner, SH Ahmed, SL Dewey, SS Negus, TE Robinson, TW Robbins, TW Robbins, TW Robbins, W Schultz, Y Kawaguchi   +55 more
core   +1 more source

An update on CRF mechanisms underlying alcohol use disorders and dependence.

Frontiers in Endocrinology, 2016
Alcohol is the most commonly used and abused substance worldwide. The emergence of alcohol use disorders, and alcohol dependence in particular, is accompanied by functional changes in brain reward and stress systems, which contribute to escalated alcohol
Isabel Marian Hartmann Quadros, Giovana Camila Macedo, Liz Paola Domingues, Cristiane Aparecida Favoretto   +3 more
doaj   +1 more source

Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction

Frontiers in Behavioral Neuroscience, 2014
Tree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates.
Fang eShen, Ying eDuan, Shu bo eJin, Nan eSui   +3 more
doaj   +1 more source

Neuroadaptations in the Cellular and Postsynaptic Group 1 Metabotropic Glutamate Receptor mGluR5 and Homer Proteins Following Extinction of Cocaine Self-administration [PDF]

, 2009
This study examined the role of group1 metabotropic glutamate receptor mGluR5 and associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration.
Ghasemzadeh, M. Behnam, Mantsch, John R., Mueller, Christopher, Seubert, Chad, Vasudevan, Preethi   +4 more
core   +2 more sources

Offspring of prenatal IV nicotine exposure exhibit increased sensitivity to the reinforcing effects of methamphetamine

Frontiers in Pharmacology, 2012
Maternal smoking during pregnancy is associated with increased substance abuse in offspring. Preclinical research shows that in utero exposure to nicotine, the primary psychoactive compound in tobacco smoke, influences the neurodevelopment of reward ...
Steven Brown Harrod, Ryan T. Lacy, Amanda J. Morgan   +2 more
doaj   +1 more source

Intravenous self administration of mercury [PDF]

QJM, 2008
A 24-year-old man attempted suicide by intravenous injection of elemental mercury. The exact quantity of injected elemental mercury was unknown. Five days later, the patient presented with painful erythema involving the anterior part of both forearms. On admission, laboratory findings disclosed the following: haemoglobin: 14.5 mmol/l, white blood cell ...
I, Marie, J, Bernet, G, Beduneau, I, Auquit-Auckbur, E, Houy-Durand, H, Levesque   +5 more
openaire   +2 more sources

The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]

, 2013
Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag, A Meister, AA Tambe, AJ Cooper, CQ Chen, DA Baker, DA Baker, Danuta Kowalczyk-Pachel, DC Carter, DP Jones, E Bald, E Bald, Elżbieta Lorenc-Koci, G Chwatko, G Lund, GJ McBean, GJ McBean, Grażyna Chwatko, H Refsum, H Sato, H Turhan, HJ Forman, HJ Forman, HL Wiener, I Barutcu, I Dalle-Donne, I Dalle-Donne, JB Dietrich, JD Uys, JE Schnitzer, JI Toohey, JJ Mieyal, JM Mato, Joanna Czyżyk, K Fijał, KM Humphries, KS Kau, KS McCully, L Pomierny-Chamioło, L Włodek, LH Lash, Lidia Włodek, M Conrad, M Iciek, M Kemp, M Muriach, MA Evans, Małgorzata Filip, Małgorzata Iciek, NL Reynaert, O Stanger, P Klatt, P Kovacic, PN Mardikian, PW Beatty, PW Kalivas, R Banerjee, R Castro, R Labib, R Labib, RA Kloner, RC Twining, S Githens, S Kandil, S Sengupta, S Zaina, SA Everett, SC Lu, SD LaRowe, SE Hyman, SH Rezkalla, SL Amen, SZ Mehanny, T Fiaschi, T Visalli, V Vitvitsky, W Tian, W Zhou, YI Kim, YM Go, YM Kupchik   +80 more
core   +2 more sources