Results 11 to 20 of about 5,219,296 (317)

Nicotine self‐administration in rats [PDF]

open access: yesBritish Journal of Pharmacology, 1984
Female Wistar rats were allowed to self‐administer nicotine solutions through indwelling jugular vein cannulae for 23 h per day for periods from three to five weeks. Two response levers were available to the rats; responding on one lever, designated the active lever, produced an immediate infusion of nicotine solution or saline.
B M, Cox, A, Goldstein, W T, Nelson
openaire   +2 more sources

Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice

open access: yesFrontiers in Psychiatry, 2020
Problems associated with the abuse of amphetamine-type stimulants, including methamphetamine (MA), pose serious health and socioeconomic issues world-wide.
Chelsea N. Brown   +14 more
doaj   +1 more source

Evaluation of Cysteine Metabolism in the Rat Liver and Kidney Following Intravenous Cocaine Administration and Abstinence

open access: yesAntioxidants, 2021
Many toxic effects of cocaine are attributed to reactive oxygen species (ROS) generated during its metabolism. Recently, it has been suggested that the biological action of ROS is often confused with endogenously generated reactive sulfur species (RSS ...
Danuta Kowalczyk-Pachel   +8 more
doaj   +1 more source

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior

open access: yesFrontiers in Behavioral Neuroscience, 2017
The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system, in which CRH exerts its effects partly via the CRH receptor subtype 1 ...
Rick E. Bernardi   +6 more
doaj   +1 more source

Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei

open access: yesFrontiers in Neuroscience, 2021
Background: Left cervical vagus nerve stimulation (l-VNS) is an FDA-approved treatment for neurological disorders including epilepsy, major depressive disorder, and stroke, and l-VNS is increasingly under investigation for a range of other neurological ...
Jackson Brougher   +7 more
doaj   +1 more source

Characteristics of patient education in self-administration of home intravenous antimicrobials: A multiple case study and logic model [PDF]

open access: yes, 2020
Self-administration of intravenous antimicrobials has been designated as a healthcare innovation practice; however, there has been limited national uptake.
Broadhurst, Daphne A
core  

Sexual & reproductive health self-care measurement tool [PDF]

open access: yes, 2023
The Sexual and Reproductive Health Self-Care Measurement Tool aims to provide a global standard approach to practical and accurate measurement of sexual and reproductive (SRH) self-care interventions, with a focus on three specific interventions: self ...
Rothschild, Clare   +2 more
core   +1 more source

The interplay between the hippocampus and the amygdala in regulating aberrant hippocampal neurogenesis during protracted abstinence from alcohol dependence

open access: yesFrontiers in Psychiatry, 2013
The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. Particularly interesting is the recent accumulating evidence that sensitized extrahypothalamic stress ...
Chitra D Mandyam
doaj   +1 more source

Usability, acceptability, and feasibility of a High-Density Microarray Patch (HD-MAP) applicator as a delivery method for vaccination in clinical settings

open access: yesHuman Vaccines & Immunotherapeutics, 2022
Background High-density microarray patch (HD-MAP) vaccines may increase vaccine acceptance and use. We aimed to ascertain whether professional immunizers (PIs) and other healthcare workers (HCWs) in Australia, a High-Income Country (HIC), found the HD ...
Cristyn Davies   +8 more
doaj   +1 more source

Chronic Fentanyl Self-Administration Generates a Shift toward Negative Affect in Rats during Drug Use

open access: yesBrain Sciences, 2021
Drug addiction is thought to be driven by negative reinforcement, and it is thought that a shift from positive affect upon initial exposure to negative affect after chronic exposure to a drug is responsible for maintaining self-administration (SA) in ...
Angela N. Dao   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy