Results 11 to 20 of about 979,898 (268)
Nicotine self‐administration in rats [PDF]
British Journal of Pharmacology, 1984 Female Wistar rats were allowed to self‐administer nicotine solutions through indwelling jugular vein cannulae for 23 h per day for periods from three to five weeks. Two response levers were available to the rats; responding on one lever, designated the active lever, produced an immediate infusion of nicotine solution or saline.
B M, Cox, A, Goldstein, W T, Nelson
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Intravenous self administration of mercury [PDF]
QJM, 2008 A 24-year-old man attempted suicide by intravenous injection of elemental mercury. The exact quantity of injected elemental mercury was unknown. Five days later, the patient presented with painful erythema involving the anterior part of both forearms. On admission, laboratory findings disclosed the following: haemoglobin: 14.5 mmol/l, white blood cell ...
I, Marie +5 more
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Frontiers in Psychiatry, 2013 The development of alcohol dependence involves elevated anxiety, low mood, and increased sensitivity to stress, collectively labeled negative affect. Particularly interesting is the recent accumulating evidence that sensitized extrahypothalamic stress ...
Chitra D Mandyam
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Human Vaccines & Immunotherapeutics, 2022 Background High-density microarray patch (HD-MAP) vaccines may increase vaccine acceptance and use. We aimed to ascertain whether professional immunizers (PIs) and other healthcare workers (HCWs) in Australia, a High-Income Country (HIC), found the HD ...
Cristyn Davies +8 more
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Brain Sciences, 2021 Drug addiction is thought to be driven by negative reinforcement, and it is thought that a shift from positive affect upon initial exposure to negative affect after chronic exposure to a drug is responsible for maintaining self-administration (SA) in ...
Angela N. Dao +5 more
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Detrimental Effects of a Retrieval-Extinction Procedure on Nicotine Seeking, but Not Cocaine Seeking
Frontiers in Behavioral Neuroscience, 2019 Retrieval-extinction memory reactivation procedures have been used to prevent the return of learned fear and drug seeking in preclinical models. These procedures first reactivate the original memory with a brief cue exposure (i.e., retrieval) session ...
Roeland F. Struik +3 more
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Frontiers in Molecular Neuroscience, 2022 The persistence of drug memory contributes to relapse to drug seeking. The association between repeated drug exposure and drug-related cues leads to cravings triggered by drug-paired cues.
Shuyi Qian +4 more
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Histamine H3 receptor: A novel therapeutic target in alcohol dependence?
Frontiers in Systems Neuroscience, 2012 The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate that histamine H3 receptor antagonists decrease alcohol drinking in ...
Pertti ePanula +3 more
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Frontiers in Behavioral Neuroscience, 2021 Alcohol use disorder (AUD) is a chronic, relapsing disorder whose genetic and environmental susceptibility components are not fully understood. Neuropeptidergic signaling has been repeatedly implicated in modulating excessive alcohol drinking, especially
Margaret A. Minnig +4 more
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Frontiers in Behavioral Neuroscience, 2010 Disrupting reconsolidation of drug-related memories may be effective in reducing the incidence of relapse. In the current study we examine whether alcohol- related memories are prone to disruption by the β -adrenergicreceptor antagonist propranolol (
Jelte A Wouda +5 more
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