Results 241 to 250 of about 7,267,221 (342)

Engineering the Link: From Genome Interaction Maps to Functional Insight

open access: yesAdvanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen   +5 more
wiley   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

open access: yesAdvanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian   +4 more
wiley   +1 more source

A Preliminary Approach to Oral Low-Dose Ketamine Self-Administration in Mice (<i>Mus musculus</i>). [PDF]

open access: yesCurr Issues Mol Biol
Rocha CA   +5 more
europepmc   +1 more source

Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

open access: yesNeuropsychopharmacology, 2015
B. Schmeichel   +11 more
semanticscholar   +1 more source

First‐Principles Modeling of Solid Solution Softening and Hardening Effects in Al–Mg–Zr–Si Aluminum Alloys

open access: yesAdvanced Engineering Materials, EarlyView.
The role of various alloying elements in face‐centered cubic aluminum on the barrier of a Shockley partial dislocation during its motion is presented. The study aims to understand how alloying atoms such as Mg, Si, and Zr affect the energy landscape for dislocation motion, thus influencing the solid solution hardening and softening in aluminum, which ...
Inna Plyushchay   +3 more
wiley   +1 more source

Fabrication‐Directed Entanglement for Designing Chiral and Anisotropic Metamaterial Foams

open access: yesAdvanced Engineering Materials, EarlyView.
This work introduces fabrication‐directed entanglement (FDE), combining viscous thread printing and topology optimization to program entangled foams with spatially patterned stiffness. By tuning coil density, FDE enables anisotropy, programmable Poisson's ratio, and chirality in foams.
Daniel Revier   +3 more
wiley   +1 more source

Validating self-administration as an agile modality for high-frequency diet quality data collection. [PDF]

open access: yesPLoS One
Manners R   +9 more
europepmc   +1 more source

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