Results 241 to 250 of about 962,917 (314)

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice. [PDF]

Neuropsychopharmacology
Gianessi CA, Haun HL, Pati D, Sides T, D'Ambrosio SL, Kelson WP, Hernandez R, Gereau GB, Boyt K, Hodge CW, Kash TL.   +10 more
europepmc   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Fixed-proportion mixtures with the α2-adrenergic agonist clonidine or lofexidine do not alter fentanyl self-administration in non-opioid-dependent male and female rats. [PDF]

J Pharmacol Exp Ther
Ortiz A, St Onge CM, Banks ML.
europepmc   +1 more source

Protocol for recording neuronal activity in food and cocaine self-administration in freely behaving mice using calcium imaging. [PDF]

STAR Protoc
Wang J, Wang B, Wang MW, Beacher NJ, Lin DT, Zhang Y.   +5 more
europepmc   +1 more source

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats. [PDF]

Front Pharmacol
Wabreha AY, Adjei N, Ladenheim B, Cadet JL, Daiwile AP.   +4 more
europepmc   +1 more source

Subjective drug-effect ratings predict cannabis self-administration in people who use cannabis daily. [PDF]

J Pharmacol Exp Ther
Shellenberg TP, Strickland JC, Regnier SD, Tolbert PT, Lake S, Wesley MJ, Stoops WW, Cooper ZD, Haney M, Lile JA.   +9 more
europepmc   +1 more source

A Progesterone Microneedle Patch for Self-Administration in the Prevention of Preterm Birth in a Mouse Model. [PDF]

Drug Des Devel Ther
Yu H, Zhu W, Yuan Z, Feng S, Huang H, Yan P.   +5 more
europepmc   +1 more source

Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity

Hesen R, Mottarlini F, Caffino L, Fennema S, Parolaro S, Guerrin CGJ, Quednow BB, Fumagalli F, Verheij MM, Homberg JR.   +9 more
europepmc   +1 more source