Results 251 to 260 of about 5,219,296 (317)

Escalated Oxycodone Self-Administration Is Associated with Activation of Specific Gene Networks in the Rat Dorsal Striatum. [PDF]

Int J Mol Sci
Wabreha AY, McCoy MT, Cadet JL, Daiwile AP.   +3 more
europepmc   +1 more source

Evaluation of Subcutaneous Contraception for Patient Self-Administration at North Florida/South Georgia Veterans Health System. [PDF]

Fed Pract
Brown JM, Pardo KM.
europepmc   +1 more source

Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity

Hesen R, Mottarlini F, Caffino L, Fennema S, Parolaro S, Guerrin CGJ, Quednow BB, Fumagalli F, Verheij MM, Homberg JR.   +9 more
europepmc   +1 more source

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Nicotine self-administration in rats

Psychopharmacology, 1995
Considering the importance of self-administration models in determining mechanisms of drug maintained behavior, we attempted to replicate the findings of nicotine self-administration by Corrigall and Coen. Male, Sprague-Dawley rats, trained on food reinforcement, acquired relatively high and stable rates of self-administration of IV nicotine bitartrate
Eric C Donny, A R Caggiula
exaly   +3 more sources

Review of self-administration

Drug and Alcohol Dependence, 1985
The reinforcing properties of drugs can be evaluated pre-clinically using self-administration procedures in laboratory animals. This paper reviews self-administration studies of the four opioid agonist/antagonist analgesics pentazocine, butorphanol, nalbuphine and buprenorphine, and compares these results to those from studies of morphine and ...
R L, Balster, S E, Lukas
openaire   +2 more sources

Self-administration cues as signals: Drug self-administration and tolerance.

Journal of Experimental Psychology: Animal Behavior Processes, 2001
There is evidence that drug-associated exteroceptive cues elicit compensatory conditional responses (CCRs) that contribute to tolerance. The authors evaluated whether interoceptive, self-administration cues (SACs) similarly contribute to tolerance. In Experiments 1 and 2, the ataxic effect of ethanol was measured in rats that self-administered (SA ...
L, Weise-Kelly, S, Siegel
openaire   +2 more sources

Self-administration of diazepam by the rat

Behavioral Biology, 1978
Male Charles River rats were offered diazepam either orally or by counterinjection over a 6-day period, with drug concentrations increasing every other day. Although diazepam intoxication was observed at all drug concentrations and with increasing severity as the drug concentration was increased, no decrease in intake ensued.
N Y, Walton, J A, Deutsch
openaire   +2 more sources

Intracranial self-administration methodologies

Neuroscience & Biobehavioral Reviews, 1987
Intracranial drug self-administration (ICSA) offers a relatively new approach for investigating the neurobiological mechanisms involved in brain reinforcement processes. Discrete brain regions responsible for the initiation of neuronal activity associated with the response-contingent delivery of a drug reinforcer can be identified using these ...
N E, Goeders, J E, Smith
openaire   +2 more sources

Nicotine self-administration in baboons

Pharmacology Biochemistry and Behavior, 1983
Two experiments were conducted in which responding maintained by nicotine and cocaine was studied under two different schedules of drug delivery. In Experiment 1, nicotine (0.01-0.32 mg/kg IV) was available under a fixed-ratio 2 timeout 15 sec reinforcement schedule.
N A, Ator, R R, Griffiths
openaire   +2 more sources