Results 71 to 80 of about 1,982 (245)

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

A Portable Colorimetric Device for Rapid Bacterial Detection with Cleavable Functional Nucleic Acid Probes for A Common Bacterial Endoribonuclease

Angewandte Chemie, EarlyView.
A simple, rapid, and portable gold‐coated filter tip‐based assay (GFTA) is developed for bacterial detection. The GFTA leverages cleavable functional nucleic acid probes as molecular recognition elements to target RNase H2, a highly conserved bacterial endoribonuclease, enabling sensitive and specific colorimetric detection of bacterial pathogens ...
Jiuxing Li, Rudi Liu, Wenqing Zhang, Bruno J. Salena, Yingfu Li   +4 more
wiley   +2 more sources

Test and Numerical Study on Blast Resistance of Main Girders Coated with Polyurea in Self-Anchored Suspension Bridges

Applied Sciences
This study investigates the blast-resistant performance of a polyurea-coated suspension bridge girder under explosive loads. The Hunan Road Bridge of Shandong was used as a case study through combined test and numerical simulation methods.
Rong Wang, Guangpan Zhou, Xiaobao Zuo
doaj   +1 more source

Seismic performance analysis of self-anchored suspension bridge steel

Frontiers Research of Architecture and Engineering, 2018
Self-anchored suspension bridge is composed of tower and its foundation, stiffened beam, main cable, sling, side pier and its foundation, auxiliary pierand its foundation. The performance and importance of the components of the bridge are different. The main tower of self-anchored suspension bridge is a very important component.
Ke Zhang, Zehua Deng, Wenheng Zhu
openaire   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Polarity‐Directed Synthesis of an Exfoliable 2D Polyoxometalate‐Based Metal‐Organic Framework for Noble Metal‐Free Alkyne Transfer Semi‐Hydrogenation

Angewandte Chemie, EarlyView.
Exfoliation of 2D nanosheets based on polyoxometalate metal‐organic frameworks (POMOFs) gives access to nanostructures with selective catalytic reactivity for the alkyne transfer semi‐hydrogenation which outperform the bulk references and rival some classical noble metal‐based catalysts.
Xusheng Dai, Yalei Zhang, Yue Zhao, Shujun Li, Nana Ma, Qingchun Xia, Yiwei Liu, Rongji Liu, Shuxia Liu, Xuenian Chen, Carsten Streb   +10 more
wiley   +2 more sources

Temperature effects on the behavior of anchorage cable of partially anchored suspension bridges

Journal of Asian Architecture and Building Engineering
A partially anchored suspension bridge is a novel type of suspension bridge. Temperature effects on the behavior of the anchorage cable of the partially anchored suspension bridge should be analyzed thoroughly. In this study, analytical solutions for the
Cunyu Cui, Yu Shen, Yongxing Li
doaj   +1 more source

Analysis of Influence of Cable Clamp Slippage on Internal Force and Alignment of Main Cable

Zhongwai Gonglu
To investigate the influence of cable clamp slippage on alignment and internal force of the main cable, a theoretical analysis method based on node coordinates of the main cable after cable clamp slippage was proposed in this paper.
ZHU Kun, LIAO Dinghui, HU Chengze, SHEN Heshun, CAO Hongyou   +4 more
doaj   +1 more source

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, EarlyView.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Research on structural vertical stiffness evaluation of track-specific suspension bridge under the action of the no-load first train

Journal of Low Frequency Noise, Vibration and Active Control
The track-specific bridge has the characteristics of a large volume of passenger traffic, narrow transverse width, and large excitation. The long-term and high-frequency operating conditions put forward strict requirements for the safety and comfort of ...
Xiaogang Li, Sihan Cen, Peng Ding, Xiaohu Chen, Xiangsheng Huang, Haoran Luo   +5 more
doaj   +1 more source