Results 41 to 50 of about 44,987 (258)
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Self-archiving in digital repositories: the roots of the past and the data of the present
Cybrarians Journal, 2014 This research deals with the topic of self-archiving, and in particular the practice of digital repositories in terms of definition, historical roots, goals, strategies, advantages, with reference to the most important initiatives and statements that ...
Wessam Benghida
doaj +1 more source
Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement
Advanced Science, EarlyView.The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang +7 more
wiley +1 more source
Retain the rights to self-archive and then self-archive
, 2006 OhioLINK is recommending that Ohio scholars retain the rights they need for self-archiving and then that they actually self-archive. From its important statement of recommendations (approved in May, released yesterday): <b> Comments </b> . There are four important things going on here.
openaire +1 more source
Self-archive unto others as ye would have them self-archive unto you [PDF]
Journal of Science Communication, 2003 Scholars and scientists do research to create new knowledge so that other scholars and scientists can use it to create still more new knowledge and to apply it to improving people's lives. They are paid to do research, but not to report their research: that they do for free, because it is not royalty-revenue from their research papers but their ...
openaire +3 more sources
Self-Archiving with Ease in an Institutional Repository: Microinteractions and the User Experience
Information Technology and Libraries, 2015 Details matter, especially when they can influence whether or not users engage with a new digital initiative that relies heavily on their support. During the recent development of MacEwan University’s institutional repository, the librarians leading the ...
Sonya Betz, Robyn Hall
doaj +1 more source
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang +18 more
wiley +1 more source
Developing strategies to ensure compliance with funders’ open access policies
Insights: The UKSG Journal, 2015 Funding bodies for higher education institutions (HEIs) in the United Kingdom (UK) have recently introduced policies with a strong focus on open access (OA).
Nancy Pontika, Dace Rozenberga
doaj +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source