Results 61 to 70 of about 4,975,440 (284)

Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides [PDF]

, 2020
Self-assembling peptides are an exemplary class of supramolecular biomaterials of broad biomedical utility. Mechanistic studies on the peptide self-assembly demonstrated the importance of the oligomeric intermediates towards the properties of the ...
Gelain, Fabrizio, Pharmaceutics, Zhang, Heyang, Vermeer, Benjamin, Medeiros-Silva, João, Yin Jerry Lau, Chun, Wezendonk, Dennie, de Vries, Renko, Remaut, Katrien, NMR Spectroscopy, Hennink, Wim E., Mandemaker, Laurens D. B., Dep Farmaceutische wetenschappen, Lau, Chun Yin Jerry, Perrone, Barbara, Bonvin, Alexandre M.J.J., Mastrobattista, Enrico, Bonvin, Alexandre M. J. J., Mandemaker, Laurens D.B., Kuemmerle, Rainer, Fontana, Federico, Sub NMR Spectroscopy, Weingarth, Markus, Hassan, Alia, Sub Inorganic Chemistry and Catalysis, Inorganic Chemistry and Catalysis, van den Dikkenberg, Joep, Afd Pharmaceutics, João Medeiros-Silva, Alexandre M. J. J. Bonvin, Katrien Remaut, Fabrizio Gelain, Dennie Wezendonk, Benjamin Vermeer, Renko de Vries, Rainer Kuemmerle, Barbara Perrone, Alia Hassan, Federico Fontana, Chun Yin Jerry Lau, Enrico Mastrobattista, Heyang Zhang, Laurens D. B. Mandemaker, Wim E. Hennink, Joep van den Dikkenberg, Markus Weingarth   +45 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Intracellular artificial supramolecules based on de novo designed Y15 peptides

Nature Communications, 2021
Self-assembling peptides (SAPs) can be used to build biomaterials, but genetically encoded SAPs have rarely been used as building blocks in cells.
Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi, Hisakazu Mihara   +5 more
doaj   +1 more source

Biomedical Applications of Self-Assembling Peptides [PDF]

, 2016
Self-assembling peptides have gained increasing attention as versatile molecules to generate diverse supramolecular structures with tunable functionality.
Radmalekshahi, Mazda, Hennink, Wim E., Pharmaceutics, Sub General Pharmaceutics, Lempsink, Ludwijn, Amidi, Maryam, Mastrobattista, Enrico   +6 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Review of Nanostructures Formed by Peptide Amphiphiles [PDF]

Nanoscale and Advanced Materials
Peptides are short-chains of amino acids that have an important role in nature regarding their activities for many biological functions, such as controlling metabolism.
Saeed Balalaie, Vaezeh Fathi Vavsari
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Characterization of elastic, thermo-responsive, self-healable supramolecular hydrogel made of self-assembly peptides and guar gum

Materials & Design, 2020
Self-assembling peptides (SAPs) show great promise in regenerative medicine and beyond. Yet, their low mechanical rigidity and limited processability hinder many of their potential applications.
Raffaele Pugliese, Fabrizio Gelain
doaj   +1 more source

Designer lipid-like peptides [PDF]

, 2011
A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Braun, Dieter, Song, Junyao, Wang, Xiaoqiang, Jerabek-Willemsen, Moran, Luo, Yuan, Baaske, Philipp, Wienken, Christoph J., Zhang, Shuguang, Corin, Karolina, Duhr, Stefan, Ravel, Deepali B., Brown, Emily   +11 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source