Results 21 to 30 of about 320,703 (322)
Self-assembling prodrugs [PDF]
Chem. Soc. Rev., 2017 Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. Self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies.
Andrew G. Cheetham +3 more
openaire +3 more sources
Electrostatic theory of viral self-assembly: a toy model [PDF]
Physica A 387, 3059 (2008), 2006 Viruses self-assemble from identical capsid proteins and their genome consisting, for example, of a long single stranded (ss) RNA. For a big class of T = 3 viruses capsid proteins have long positive N-terminal tails. We explore the role played by the Coulomb interaction between the brush of positive N-terminal tails rooted at the inner surface of the ...
arxiv +1 more source
Kinetics of viral self-assembly: the role of ss RNA antenna [PDF]
Phys. Rev. E 75, 051901 (2007), 2006 A big class of viruses self-assemble from a large number of identical capsid proteins with long flexible N-terminal tails and ss RNA. We study the role of the strong Coulomb interaction of positive N-terminal tails with ss RNA in the kinetics of the in vitro virus self-assembly.
arxiv +1 more source
Fabrication of Blood Capillary Models for Live Imaging Microarray Analysis
Micromachines, 2020 Conventional microarray analysis usually deals with the monolayer or two-dimensional (2D) assays for the high-throughput screening applications. Even though these cell-based assays are effective for preliminary screening at least to have information on ...
Muhammad Asri Abdul Sisak +4 more
doaj +1 more source
Gravity enables selfâassembly
Natural Sciences, 2022 Crystallization of granular assemblies has broad implications for rapid and scalable creation of architected materials with applications ranging from structural materials to microarchitected battery electrodes.
Ivan Grega +3 more
doaj +1 more source
Modeling capsid self-assembly: Design and analysis [PDF]
Phys. Biol. 7 (2010) 045001, 2010 A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms. The fact that different viruses adopt similar structural forms is an indication of a common underlying design ...
arxiv +1 more source
Self-assembly of self-assembled molecular triangles
Journal of Chemical Sciences, 2014 A rare variety of self-assembled molecular triangle [Pd3(bpy)3(imidazolate)3](NO3)3, 1 is prepared by the combination of Pd(bpy)(NO3)2 with imidazole, at 1:1 ratio, in acetonitrile-water. Deprotonation of imidazole happened during the course of the complexation reaction where upon the metallomacrocycle is formed. The bowl-shaped trinuclear architecture
Venkatachalam Ramkumar +2 more
openaire +3 more sources
Nature Communications, 2022 The atomic structure of heterogeneous catalysts is usually a blackbox. Here the authors demonstrate large-scale machine learning atomic simulations help to resolve the catalyst structure and reaction mechanism of encapsulated PtSnO x clusters in zeolite ...
Sicong Ma, Zhi-Pan Liu
doaj +1 more source
Optimized Interactions for Targeted Self-Assembly: Application to Honeycomb Lattice [PDF]
, 2005 We devise an inverse statistical-mechanical methodology to find optimized interaction potentials that lead spontaneously to a target many-particle configuration. Target structures can possess varying degrees of disorder, thus extending the traditional idea of self-assembly to incorporate both amorphous and crystalline structures as well as ...
arxiv +1 more source
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Nature Communications, 2022 Studying the specific roles of macrophage subsets has been hampered by a lack of subset-specific probes. Here the authors report an M1 selective fluorescent probe named CDr17, and demonstrate the suitability of this probe for tracking M1 macrophages in ...
Heewon Cho +9 more
doaj +1 more source