Results 91 to 100 of about 1,770,133 (289)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Assessment of Heart Failure Patients' Interest in Mobile Health Apps for Self-Care: Survey Study. [PDF]

, 2019
BackgroundHeart failure is a serious public health concern that afflicts millions of individuals in the United States. Development of behaviors that promote heart failure self-care may be imperative to reduce complications and avoid hospital re ...
Aoki, Kymberly, Arnold, Corey, Fonarow, Gregg, Lan, Esther, Ong, Michael, Sohn, Albert, Speier, William   +6 more
core   +1 more source

Health coaching for people with long-term conditions and multimorbidity: a mixed methods prospective service evaluation of Structured Agenda-free Coaching Conversations (StACC) in UK primary care

BMC Public Health
Background Enhanced patient engagement has been linked to health service sustainability. The Structured Agenda-free Coaching Conversation (StACC) model aims to support people with one or more long-term conditions through a strengths-based approach ...
Kate Henry, Austen El-Osta, Kathleen Leedham-Green   +2 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Functional outcome of patients with spinal cord injury: rehabilitation outcome study [PDF]

, 1999
Objective: To increase our knowledge of neurological recovery and functional outcome of patients with spinal cord injuries in order to make more successful rehabilitation programmes based on realistic goals.Design: Descriptive analysis of data gathered ...
G A Mulder, Hussey RW, J W Groothoff, Lazar RB, M C Schönherr, Rogers JC, W H Eisma, Waters RL, Waters RL, Waters RL, Welch RD, World Health Organization, Yarkony GM   +12 more
core   +1 more source

Using context mapping for planning implementation of movement behavior change in physiotherapy

BMC Health Services Research
Background Physiotherapists often lack a comprehensive understanding of self-management and encounter challenges in providing self-management support. The Keep Moving Support Tool (KMST) was developed to support physiotherapists in their role as health ...
Sofie van Rongen, Joan M. Dallinga, Anita Feleus, Ingrid Rosbergen, Alice Schut, Myrenka Bik, Petra Siemonsma, Sanne I. de Vries, Arlette E. Hesselink   +8 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Helplessness or self care? : a study of nursing practice with depressed patients in an in-care setting : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Nursing Studies at Massey University [PDF]

, 1982
This study was conducted to investigate the practice of nurses when working with depressed patients in an in care setting. A survey of the literature shows that the role commonly prescribed for nurses who work in psychiatric settings is one that ...
Butterfield, Shona
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