Results 41 to 50 of about 1,565,438 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On‐feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation

Experimental Physiology
Orthostatic stress reduces venous return and stroke volume (SV), risking cerebral hypoperfusion despite autonomic compensation. Although lower‐limb counterpressure manoeuvres improve cerebral perfusion in upright posture, their effects on cerebral blood ...
Jun Sugawara, Marina Fukuie, Tsubasa Tomoto, Takashi Tarumi, Ai Hirasawa, Shigeki Shibata   +5 more
doaj   +1 more source

What are community perspectives and experiences around GLP-1 receptor agonist medications for weight loss? A cross-sectional survey study in the UK

BMJ Public Health
Introduction Obesity is a critical public health challenge globally. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated significant efficacy in weight loss; however, their adoption is influenced by various individual and societal ...
Ashley Kieran Clift, Austen El-Osta, Vivian N Liu, David Roy Huang, Nadja Auerbach, Mahmoud Al-Ammouri   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Care and the self

Medicine Anthropology Theory, 2021
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Lauren Wynne
doaj  

THE SELF-CARE MATRIX: A UNIFYING FRAMEWORK FOR SELF-CARE

, 2020
BACKGROUND: There is resurgent interest in the concept and practice of self-care as a means to improve the health, wellness and wellbeing of individuals, and as an avenue to mitigate financial pressures and growing demands on health and social care systems worldwide.
El-Osta, A, Webber, D, Gnani, S, Banarsee, R, Mummery, D, Majeed, A, Smith, P   +6 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pain and Cognitive Concerns Among Breast Cancer Survivors: The Mediating Role of Substance Use Coping

Cancer Medicine
Context Bodily pain and cognitive concerns are both prevalent and share similar underlying mechanisms. A few studies have suggested that pain and cognitive concerns may be linked through substance use coping; however, this relationship remains unclear ...
Yesol Yang, Alai Tan, Leorey N. Saligan, Diane Von Ah   +3 more
doaj   +1 more source

FROM SELF-CARE TO COLLECTIVE CARE

Sur: International Journal on Human Rights, 2020
Human Rights Defenders (HRDs) across the world report a common experience of closing space for opposition to oppressive repositories of power, whether at the hand of government or the private sector. One of the strategies of resistance developed by HRDs
Lisa Chamberlain
doaj