Results 41 to 50 of about 18,428 (265)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Study of Failure Mode and Ultimate Bearing Capacity for Self-Centering SMA Connection

Buildings
An innovative self-centering shape memory alloy (SMA) connection that is used in a steel frame beam-column joint was developed to improve the energy dissipative capacity and self-centering capacity, and reduce the residual deformation.
Xiaozhu Fu, Shangwen Liu, Chaobin Jin, Shujun Hu   +3 more
doaj   +1 more source

Low-Cyclic Loading Tests of Self-Centering Variable Friction (SCVF) Brace

Shock and Vibration, 2020
A novel assembled self-centering variable friction (SCVF) brace is proposed which is composed of an energy dissipation system, a self-centering system, and a set of force transmission devices.
Qingguang He, Yanxia Bai, Weike Wu, Yongfeng Du   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Design and Simulation of Reset Mechanism of Self-centering Center Rest for Grinding Machine

Jixie chuandong, 2019
As an auxiliary fixture in the grinding process of slender shaft parts such as lead screw and crankshaft and so on, the self-centering center rest is of great significance to the processing accuracy of slender shaft parts.
Yongqiang Zhao, Ruichao Li, Hongling Hou, Changqian Wang, Fei Wang, Haixia Du   +5 more
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Shape Memory Alloys for Self-Centering Seismic Applications: A Review on Recent Advancements

Machines
Shape memory alloys (SMAs) have emerged as promising materials for self-centering seismic applications due to their unique properties of superelasticity and shape memory effect. This review article examines recent advancements in the use of SMAs for self-
Girolamo Costanza, Samuel Mercuri, Ilaria Porroni, Maria Elisa Tata   +3 more
doaj   +1 more source