Results 61 to 70 of about 18,428 (265)

Analytical Study of Force–Displacement Behavior and Ductility of Self-centering Segmental Concrete Columns

International Journal of Concrete Structures and Materials, 2017
In this study the behavior of unbonded post-tensioned segmental columns (UPTSCs) was investigated and expressions were proposed to estimate their ductility and neutral axis (NA) depth at ultimate strength.
Reza Hassanli, Osama Youssf, Julie Mills, Mostafa Fakharifar   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Large-Scale Testing of a Novel Self-Centering Brace with U-Shaped Plates for Seismic Energy Dissipation

CivilEng
Energy-dissipating braces are novel structural components as they not only accommodate the seismic energy demand but also enhance both the flexibility and overall earthquake resistance of the structure, preventing brittle or non-ductile behavior.
Onur Gurler, Ozgur Ozcelik, Sadik Can Girgin, Atakan Aksoy, Cagri Cetik   +4 more
doaj   +1 more source

How Do Nurses Apply Personal Knowing to Patient Care? A Grounded Theory Study

Journal of Client-centered Nursing Care, 2021
Background: Personal Knowing (PK) is an expression of self-knowledge concerning others. Besides, PK is the most difficult as well as the most essential pattern of knowing in nursing.
Forough Rafii, Fereshteh Javaheri Tehrani, Alireza Nikbakht Nasrabadi, Shabnam Shariatpanahi   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Experimental Study on the Seismic Behavior of CFST Self-Centering Rocking Bridge Piers

Buildings
Compared to conventional reinforced concrete (RC) piers, self-centering rocking piers exhibit better seismic resilience and sustain minor damage. However, their construction typically relies on prefabrication.
Wei Lu, Yu Zou, Xingyu Luo, Jun Song, Haiqing Li   +4 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source