Results 61 to 70 of about 481,938 (332)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Self‐Assembled Nanostructures of Quantum Dot/Conjugated Polymer Hybrids for Photonic Synaptic Transistors with Ultralow Energy Consumption and Zero‐Gate Bias (Adv. Funct. Mater. 6/2022) [PDF]

, 2022
Ender Ercan, Yan‐Cheng Lin, Weichen Yang, Wen‐Chang Chen   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Extrativismo e Produção de Alimentos como Estratégia de Reprodução de Agricultores Familiares do Assentamento Seringal, Amazônia Meridional

Revista de Economia e Sociologia Rural
Resumo: A soberania alimentar do agricultor familiar está relacionada à transformação do agroecossistema, articulando a geração de trabalho e renda e sua capacidade de autoprodução de alimentos. Assim, este trabalho tem por objetivo investigar a produção
Keller Regina Soares, Esvanio Edipo da Silva Ferreira, Santino Seabra Junior, Sandra Mara Alves da Silva Neves   +3 more
doaj   +1 more source

Assessment of the photovoltaic potential at urban level based on 3D city models: A case study and new methodological approach [PDF]

, 2017
The use of 3D city models combined with simulation functionalities allows to quantify energy demand and renewable generation for a very large set of buildings.
Duminil, Eric, Eicker, Ursula, Romero Rodríguez, Laura, Sánchez Ramos, José   +3 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Evaluation of Load Matching Indicators in Residential PV Systems-the Case of Cyprus

Energies, 2020
Three load matching indicators (self-consumption rate, self-sufficiency rate, loss of load probability) and the CO2 emissions were evaluated for 55 Cypriot households with 3 kWp rooftop photovoltaic (PV) generators.
Vladimir Z. Gjorgievski, Nikolas G. Chatzigeorgiou, Venizelos Venizelou, Georgios C. Christoforidis, George E. Georghiou, Grigoris K. Papagiannis   +5 more
doaj   +1 more source