Results 61 to 70 of about 1,810,939 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effect of self-modeling and self-controlled feedback on the performance of professional swimmers and waterpolo players

Sports Medicine and Health Science
Self-modeling (SM) and self-control (SC) feedback can be presented as two solutions for learning improvement. Therefore, the aim of the present study was to investigate the effects of SM and SC feedback on 100-m freestyle performance of professional ...
Masoud Mirmoezzi, Mansour Sayyah, Morteza Taheri, Khadijeh Irandoust, Mandana Sangari, Fatemeh Mirakhori, Ali Seghatoleslami, Lee Hill, Katja Weiss, Beat Knechtle, Amine Ghram   +10 more
doaj   +1 more source

Modelling and feedback control design for quantum state preparation [PDF]

, 2005
The goal of this article is to provide a largely self-contained introduction to the modelling of controlled quantum systems under continuous observation, and to the design of feedback controls that prepare particular quantum states.
Mabuchi, Hideo, Stockton, John K., van Handel, Ramon   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Effect of Negative Feedback on Positive Beliefs in Self-Deception

Frontiers in Psychology, 2019
In the present study, we applied the forward-looking paradigm to examine how positive beliefs appear in self-deception and to further reveal the influence of negative feedback on positive beliefs to decrease self-deception.
Juan Liu, Juan Liu, Wenjie Zhang, Wenjie Zhang, Youlong Zhan, Lixin Song, Peipei Guan, Dan Kang, Jie Jian, Jie Jian, Ronghua Cai, Mei Li, Mei Li   +12 more
doaj   +1 more source

Preparing Students for Success on Examinations: Readiness Assurance Tests in a Graduate-Level Statistics Course [PDF]

, 2016
Formative feedback is one way to foster students' readiness for statistics examinations. The use of Readiness Assurance Tests was examined as an educational intervention in which feedback was provided for both correct and incorrect responses in a ...
Bartlett Ellis, Rebecca J., Carter-Harris, Lisa, MacLaughlin, Pam   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Contextual Interference Effect in Bandwidth and Self-Control Feedback Conditions on Relative and Absolute Timing Learning

Annals of Applied Sport Science, 2016
This study aims to better understand the effect of practice schedule and feedback providing types. In two separate experiments the contextual interference effect in bandwidth and self-control feedback conditions on relative and absolute timing learning ...
Amir Shams, Seyedeh Mansoreh Naeimi Tajdar   +1 more
doaj