Results 41 to 50 of about 10,754,820 (236)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
State, Security, and Economy in Afghanistan: Current Challenges, Possible Solutions
, 2007 Recommendations in this report address three broad issue areas key to ongoing state- and security-building efforts in Afghanistan: political reform, regional relationships, and international priorities.
Liechtenstein Institute on Self-Determination
core +1 more source
Indigenous Self-Determination in Australia [PDF]
, 2020 Histories of the colonisation of Australia have recognised distinct periods or eras in the colonial relationship: 'protection' and ‘assimilation’.
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Iran, Its Nuclear Ambitions, the Region, and the West
, 2006 The report addresses the ongoing Iranian nuclear crisis and related policy issues, Iran’s nuclear aspirations based on the internal politics of the country, Iran’s interstate relations and the role it occupies within the Middle East and Central Asia, and
Liechtenstein Institute on Self-Determination
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Self-determination theory and the welfare of employees [PDF]
Zbornik Radova Filozofskog Fakulteta u Prištini, 2013 The objective of this article is to give an account of the psychological welfare of employees in the context of self-determination theory. SDT represents an approach to human motivation and personality that uses traditional empirical methods which make ...
Ranđelović Kristina M. +1 more
doaj
Stability and Viability in Afghanistan
, 2003 This report focused on the political history of Afghanistan, the main issues and lessons in building viable, democratic state systems, lessons from international case studies on decentralization and nation building, and their applicability to post-2001 ...
Liechtenstein Institute on Self-Determination
core +1 more source