Results 51 to 60 of about 10,754,820 (236)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Evaluating the Use of Automated Feedback on Student Motivation

INNOVATIONS in Pharmacy, 2018
Objective: Autonomy-support and quality feedback have been shown to significantly impact student learning. Unfortunately, quality feedback is often very time consuming. The goal of this study was to examine the autonomy-supportive potential from feedback
Leah Simpson, Mikael Jones, Stacy Taylor
doaj   +1 more source

Autonomy supportive and reactance supportive inoculations both boost resistance to propaganda, as mediated by state autonomy but not state reactance

Social Influence, 2021
We tested two counter-propaganda strategies for boosting peoples’ resistance to extremist propaganda, one based on Self-Determination Theory and one based on Psychological Reactance theory.
Douglas Wilbur, Kennon M. Sheldon, Glen Cameron   +2 more
doaj   +1 more source

The interplay between basic psychological needs and sleep in self-determination theory

, 2023
Grounded in self-determination theory (SDT), this chapter provides an overview of the nascent literature on the dynamic interplay between basic psychological needs and the physical need for sleep, thereby covering three recent lines of research.
Campbell, Rachel, Ryan, Richard M.editor, Vansteenkiste, MaartenPP078020000369170000-0001-6983-3607F8565E36-F0ED-11E1-A9DE-61C894A0A6B4   +2 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Self-Determination Research: Current and Future Directions

Behavioral Sciences
This article summarizes the history, current status, and future directions of self-determination research across the globe, with a focus on applications to the education of students with intellectual and developmental disabilities and their transition ...
Kathryn M. Burke, Karrie A. Shogren, Andrea Parente, Abdulaziz Alsaeed, Austin M. Myers, Shawn Aleong   +5 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Self-Determination Theory. Characteristics and applications [PDF]

, 2023
openLa Self-Determination Theory (SDT), o Teoria dell'Autodeterminazione, è un approccio teorico ampiamente studiato nell'ambito della psicologia della motivazione e del benessere. Sviluppata da Edward L. Deci e Richard M.
CORNACCHIONE, DANIELE
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source