Results 71 to 80 of about 1,350,060 (297)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Autonomy supportive and reactance supportive inoculations both boost resistance to propaganda, as mediated by state autonomy but not state reactance

Social Influence, 2021
We tested two counter-propaganda strategies for boosting peoples’ resistance to extremist propaganda, one based on Self-Determination Theory and one based on Psychological Reactance theory.
Douglas Wilbur, Kennon M. Sheldon, Glen Cameron   +2 more
doaj   +1 more source

A self-determination theory perspective on parenting. [PDF]

Canadian Psychology / Psychologie canadienne, 2008
Parents are confronted with a fundamental but often difficult task: teaching children the values and regulations necessary to function effectively in society while also nurturing children’s drive to express themselves and to pursue their unique interests and capacities.
Joussemet, Mireille, Landry, Renée, Koestner, Richard   +2 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Self-determination theory and the welfare of employees [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2013
The objective of this article is to give an account of the psychological welfare of employees in the context of self-determination theory. SDT represents an approach to human motivation and personality that uses traditional empirical methods which make ...
Ranđelović Kristina M., Ranđelović Dušan J.   +1 more
doaj  

Evaluating the Use of Automated Feedback on Student Motivation

INNOVATIONS in Pharmacy, 2018
Objective: Autonomy-support and quality feedback have been shown to significantly impact student learning. Unfortunately, quality feedback is often very time consuming. The goal of this study was to examine the autonomy-supportive potential from feedback
Leah Simpson, Mikael Jones, Stacy Taylor
doaj   +1 more source

The motivational pull of video game feedback, rules, and social interaction: Another self-determination theory approach [PDF]

, 2017
This paper argues that most video game enjoyment can be understood in terms of the type of feedback used, the rules set out by the game and the social elements of the game - concepts that have been identified as critical to video games.
Rogers, Ryan
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Self-Determination Research: Current and Future Directions

Behavioral Sciences
This article summarizes the history, current status, and future directions of self-determination research across the globe, with a focus on applications to the education of students with intellectual and developmental disabilities and their transition ...
Kathryn M. Burke, Karrie A. Shogren, Andrea Parente, Abdulaziz Alsaeed, Austin M. Myers, Shawn Aleong   +5 more
doaj   +1 more source