Results 61 to 70 of about 299,056 (248)
Jurnal Empati, 2017 Penelitian ini bertujuan untuk mengetahui hubungan antara self disclosure dengan kecemasan menghadapi pensiun pada pegawai PT. PLN (Persero) Wilayah Semarang. Subjek penelitian adalah 75 pegawai yang berusia 51 hingga 55 tahun di PT.
Chanya Paripurastu Sasongko +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hubungan Antara Pengungkapan-Diri dan Kepuasan Pernikahan dengan Dimediasi oleh Intimasi
Psikologika: Jurnal Pemikiran dan Penelitian Psikologi, 2017 The present study was aimed to examine the relationship between self-disclosure and marital satisfaction, and whether the relation between self-disclosure and marital satisfaction meditated by intimacy.
Arif Romdhon, Hepy Wahyuningsih
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Why We Disclose on Social Media? Towards a Dual-Pathway Model
Behavioral SciencesGrounded in social penetration theory and social capital theory, this study aims to investigate how social media self-disclosure influences bridging and bonding online social capital, and how these in turn affect users’ loneliness and online ...
Qiyu Bai, Qi Dan, Yumin Choi, Siyang Luo
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Hubungan Antara Pengungkapan-Diri dan Kepuasan Pernikahan dengan Dimediasi oleh Intimasi
Psikologika: Jurnal Pemikiran dan Penelitian Psikologi, 2012 The present study was aimed to examine the relationship between self-disclosure and marital satisfaction, and whether the relation between self-disclosure and marital satisfaction meditated by intimacy.
Arif Romdhon, Hepi Wahyuningsih
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source