Results 71 to 80 of about 299,056 (248)

Relationship between loneliness and post-traumatic growth in patients with gynecologic malignancies: the mediating role of self-disclosure and psychological resilience

BMC Psychology
Background To explore the relationship between loneliness and post-traumatic growth, with a focus on the mediating role of psychological resilience and self-disclosure. Methods This study was a cross-sectional survey using the Loneliness Scale for Cancer
Ting Liao, Xiaoying Tian, Tianrong Huang, Yihong Wu, Xinxia Yu, Simeng Song   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

AI Chatbot Acceptance and Self-Disclosure among Guidance and Counseling Students: Testing the Technology Acceptance Model in Counselor Education

Bulletin of Counseling and Psychotherapy
Self-disclosure is a core competency in counseling, yet many students experience psychological barriers, such as fear of judgment and stigma, that inhibit openness.
Venty Venty, Partono Partono, Eka Sari Setianingsih, Ismah Ismah   +3 more
doaj   +1 more source

EFEKTIVITAS KONSELING RASIONAL EMOTIF TEKNIK FORMULA ABC DAN TEKNIK ASERTIF ADAPTIF UNTUK MENINGKATKAN SELF-DISCLOSURE SISWA KELAS X JASA BOGA SMK NEGERI 2 SINGARAJA TAHUN PELAJARAN 2013/2014

Jurnal Ilmiah Bimbingan Konseling Undiksha, 2014
Penelitian ini bertujuan untuk menganalisis perbedaan efektivitas konseling rasional emotif teknik Formula ABC dengan konseling rasional emotif teknik Asertif Adaptif untuk meningkatan Self-Disclosure siswa kelas X Jasa Boga SMK Negeri 2 Singaraja. Jenis
Ni Wayan Suarningsih, Ni Ketut Suarni, Dewi Arum Widhiyanti Metra Putri   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Perceived social support, emotional self-disclosure, and posttraumatic growth in children following a typhoon: a three-wave cross-lagged study

European Journal of Psychotraumatology
Objective: We aimed to elucidate the temporal relationship between perceived social support, emotional self-disclosure and posttraumatic growth (PTG) in children.Method: The super typhoon Lekima occurred on August 10, 2019, in China.
Zijian He, Yifan Li, Yingying Ye, Xiao Zhou   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source