Results 41 to 50 of about 14,062 (252)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Looking for Age Differences in Self-Driving Vehicles: Examining the Effects of Automation Reliability, Driving Risk, and Physical Impairment on Trust

Frontiers in Psychology, 2019
PurposeSelf-driving cars are an extremely high level of autonomous technology and represent a promising technology that may help older adults safely maintain independence.
Ericka Rovira, Anne Collins McLaughlin, Richard Pak, Luke High   +3 more
doaj   +1 more source

Criminal liability of the self-driving cars for the injury caused by it [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2020
The advancement of technology has led to the production of a car that does not require a human driver. In June 2016, the first self-driving car was successfully tested in Iran and in the same month their use was banned by traffic police chief due to lack
Mohammad Reza Barzegar, Gholam Hussein Elham   +1 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Hierarchical reinforcement learning for self‐driving decision‐making without reliance on labelled driving data

IET Intelligent Transport Systems, 2020
Decision making for self‐driving cars is usually tackled by manually encoding rules from drivers’ behaviours or imitating drivers’ manipulation using supervised learning techniques.
Jingliang Duan, Shengbo Eben Li, Yang Guan, Qi Sun, Bo Cheng   +4 more
doaj   +1 more source

Self Driving Car in a Constrained Environment

, 2022
The purpose of the research is to build a machine learning model which can drive a car on the tracks of Udacity’s Car simulator without any human intervention. This is achieved by mimicking the human driving behaviour in the training mode on a track. A dataset is generated by the simulator based on the human driving behaviour in the training mode and a
B. Harish, Durairaj Thenmozhi
openaire   +2 more sources

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato, Alessia Giugno, Miriam Sturniolo, Enrico Fratto, Pio Zoleo, Francesca Felicia Operto, Ilaria Sammarra, Antonio Gambardella   +7 more
wiley   +1 more source

Self‐Assembled Crystalline Peptoid Nanomaterials as Metal‐Free Enzyme Mimics for Enhanced Carbon Dioxide Hydration and Precipitation

Advanced Functional Materials, EarlyView.
Inspired by metal‐free carbonic anhydrases (CAs) that achieve efficient catalysis without metal cofactors, we herein report a sequence‐defined supramolecular peptoid platform that mimics metal‐free CAs and exhibits hydrolytic activity via a supramolecular assembly‐mediated proton‐transfer mechanism.
Progyateg Chakma, Ying Chen, Thi Kim Hoang Trinh, Anthony R. Perez, Jonathan Gil, Maria Casco Hidalgo, Botao Hao, Kyle Whitaker, Chun‐Long Chen   +8 more
wiley   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source